Alam M, McGinty D (2017) Acute effects of alcohol on sleep are mediated by components of homeostatic sleep regulatory system: An Editorial Highlight for ‘Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption’ on page 710. J Neurochem 142(5):620-623.. doi: 10.1111/jnc.14100
Summary: In the study published in 2017, Sharma and colleagues report that the wake-promoting BF cholinergic neurons are critically involved in the acute alcohol-induced sleep promoting response and that extracellular adenosine buildup in the BF mediates this response. Using 192-IgG-SAP (Cat. #IT-01), they ablated BF cholinergic neurons unilaterally and compared extracellular adenosine levels on lesioned versus non-lesioned sides after local delivery of alcohol via reverse microdialysis. They found that adenosine levels were significantly lower (nearly 50%) on the side with a loss of cholinergic neurons.
Related Products: 192-IgG-SAP (Cat. #IT-01)