Author name: Kristen Hartman

LNGFR targets the Wnt/β-catenin pathway and promotes the osteogenic differentiation in rat ectomesenchymal stem cells

Li G, Liu J, Wang Y, Yang K, Zhao M, Xiao Y, Wen X, Liu L (2017) LNGFR targets the Wnt/β-catenin pathway and promotes the osteogenic differentiation in rat ectomesenchymal stem cells. Sci Rep 7(1):11021. doi: 10.1038/s41598-017-11555-9 PMID: 28887537 Objective: To demonstrate that nuclear β-catenin was upregulated during ectomesenchymal stem cells (EMSC) osteogenic differentiation. Summary: […]

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EV20-Sap, a novel anti-HER-3 antibody-drug conjugate, displays promising antitumor activity in melanoma

Capone E, Giansanti F, Ponziani S, Lamolinara A, Iezzi M, Cimini A, Angelucci F, Sorda R, Laurenzi V, Natali PG, Ippoliti R, Iacobelli S, Sala G (2017) EV20-Sap, a novel anti-HER-3 antibody-drug conjugate, displays promising antitumor activity in melanoma. Oncotarget 8(56):95412-95424. doi: 10.18632/oncotarget.20728 PMID: 29221137 Objective: Using EV20 (Anti-Her3)-SAP to target Her3 positive melanoma Summary:

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A novel method for obtaining highly enriched Schwann cell populations from mature monkey nerves based on in vitro pre‑degeneration

Wang G, Ma Z, Cao L, Yan G, Wang Y, Jin Y, Shen H, Zhang Y, Xu X, Chen X, Shen Z (2017) A novel method for obtaining highly enriched Schwann cell populations from mature monkey nerves based on in vitro pre‑degeneration. Mol Med Rep 16(5):6600-6607. doi: 10.3892/mmr.2017.7427 PMID: 28901508 Objective: To identify a novel

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Inotuzumab ozogamicin: First global approval

Lamb YN (2017) Inotuzumab ozogamicin: First global approval. Drugs 77(14):1603-1610. doi: 10.1007/s40265-017-0802-5 PMID: 28819740 Summary: Inotuzumab ozogamicin, an anti-CD22 monoclonal antibody-calicheamicin conjugate, has received its first global approval as a promising treatment option. This novel therapy shows potential for addressing certain hematological malignancies and represents a significant advancement in the field of cancer treatment.

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Nerve growth factor and its receptors on onset and diagnosis of ovarian cancer

Yu X, Liu Z, Hou R, Nie Y, Chen R (2017) Nerve growth factor and its receptors on onset and diagnosis of ovarian cancer. Oncol Lett 14(3):2864-2868. doi: 10.3892/ol.2017.6527 PMID: 28928825 Objective: To investigate the effect of nerve growth factor (NGF) and its receptors on the onset and diagnosis of ovarian cancer. Summary: NGF and

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Spinal microglia are required for long-term maintenance of neuropathic pain

Echeverry S, Shi XQ, Yang M, Huang H, Wu Y, Lorenzo L-E, Perez-Sanchez J, Bonin RP, De Koninck Y, Zhang J (2017) Spinal microglia are required for long-term maintenance of neuropathic pain. Pain 158:1792-1801.. doi: 10.1097/j.pain.0000000000000982 Summary: Selective depletion of spinal microglia in male rats with the targeted immunotoxin Mac-1-SAP and blockade of brain derived

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Got an itch? Bombesin-SAP may help

Targeting Topics /

Itch Induces Conditioned Place Aversion in Mice. Mu, D, & Sun, Y-G. (2017). Neuroscience Letters, http://dx.doi.org/10.1016/j.neulet.2017.08.046 “Consistently, ablation of itch‐specific neurons that express gastrin‐releasing peptide receptor in the spinal cord also abolished itch‐induced Conditioned Place Aversion (CPA), confirming that itch‐induced CPA is dependent on the spinal itch circuit.” Mice were given a single intrathecal injection

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Cholera Toxin B-Saporin: A targeting tool to study ALS

Targeting Topics /

Phrenic long-term facilitation following intrapleural CTB-SAP-induced respiratory motor neuron death. Nichols NL, Craig TA, & Tanner MA. Respir Physiol Neurobiol. 2018 Oct;256:43-49. doi: 10.1016/j.resp.2017.08.003. Epub 2017 Aug 16. There are currently no approved treatment options to significantly preserve/restore breathing capacity in patients with Amyotrophic lateral sclerosis (ALS). Intrapleural CTB-SAP (Cat. #IT-14) mimics aspects of ALS. This

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Connective tissue, glial and neuronal expressions in testis of the African giant rat (Cricetomys gambianus)

Falade TE, Olude MA, Mustapha OA, Mbajiorgu EF, Ihunwo AO, Olopade JO, Oke BO (2017) Connective tissue, glial and neuronal expressions in testis of the African giant rat (Cricetomys gambianus). J Morphological Sciences 34(03):186-193. doi: 10.4322/jms.109117 Objective: To investigate the expression of connective tissue (Collagens I and III), glia and neuronal markers in the testis

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Parkinson’s Disease, Unsteady Gait, and the ChAT Walk

Targeting Topics /

Selective Cholinergic Depletion of Pedunculopontine Tegmental Nucleus Aggravates Freezing of Gait in Parkinsonian Rats.  Xiao, H, Li, M, Cai, J, et al. (2017). Neurosci Lett [Epub 10 August 2017]. PMID: 28803956 Many patients with advanced Parkinson’s disease suffer from gait and postural impairments.  The authors used Anti-ChAT-SAP (Cat. #IT-42) to specifically lesion neurons in the Pedunculopontine Tegmental Nucleus (PPTg) to examine the

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