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Lesion of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption.

Sharma R, Sahota P, Thakkar M (2017) Lesion of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption. J Neurochem 142:710-720.. doi: 10.1111/jnc.14054

Summary: This project examined the sleep-promoting effect of alcohol and which neurons in the brain are involved in the process. 192-IgG-SAP (Cat. #IT-01; 0.3 µg/500 nL/side) was administered through bilateral basal forebrain infusions in rats. Based on the results, the authors suggest that alcohol promotes sleep by increasing extracellular adenosine via its action on cholinergic neurons of the basal forebrain.

Related Products: 192-IgG-SAP (Cat. #IT-01)