tt2012

There are eight known metabotropic glutamate receptors (mGluR) playing diverse roles in brain function and pathology. They are 7-transmembrane domain receptors involved in learning, memory, anxiety, synaptic plasticity, and pain perception. The ligand for these receptors is glutamate, which functions as an excitatory neurotransmitter. mGluR2 is involved in the inhibition of the cAMP cascade. Potentiation

Tag-targeted toxins are new conjugates in the Targeted Toxins family. Antibodies specific for tags on expressed proteins are bound to the ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis). The conjugate binds to your tag that is expressed on the cell surface and then internalizes by antibody-mediated endocytosis. Saporin breaks away from