tt2011

Cover Article: Targeted Toxins – Cheaper and Quicker than Knockouts

Cell-specific targeting and removal: cheaper and quicker than knockouts with high impact results. Knockout models are helpful tools in scientific research. They have been useful in studying and modeling in all sorts of research in biology; so much so that the pioneers – Smithies, Capecchi and Evans – won a well-deserved Nobel Prize for Physiology …

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Targeting Trends 2011 Newsletter

Read the 2011 Newsletters and recent scientific references 2011, issue 1: Targeted Lesion of Caudal Brainstem Catecholamine Neurons Reveals Their Role in Symptoms of Fatigue / by Goehler LE, Gaykema RPA / featuring Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18) SFN Poster of the Year Targeting Talk: Time Course for Toxins, Custom Mouse IgM Conjugate and …

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Targeting Tools: Neurotensin Conjugates

Neurotensin is a 13 amino acid peptide found in the brain and spinal cord (first characterized by Carraway and Leeman1). It affects pituitary hormone release, interacts with the dopaminergic system, and is involved in vasodilation and hypotension. It can also modulate pain perception. Advanced Targeting Systems is pleased to announce two conjugates that will be …

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Cover Article: Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity

Contributed by Tamara King and Frank Porreca Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA A common symptom of patients with neuropathic pain is spontaneous pain, often described as burning. Some patients also suffer from pain elicited by normally non-noxious stimuli, such as touch, referred to as allodynia. Preclinical studies have …

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Targeting Tools: FGF-2 Human Recombinant

Basic fibroblast growth factor (FGF-2) is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration …

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Targeting Article: Basigin-2 (EMMPRIN), a Prognostic Marker, is a Dynamic Portal of Entry into Cancer Cells

by Leonardo R. Ancheta and Douglas A. Lappi, American Association of Cancer Research abstract #5218 Basigin-2 (EMMPRIN) is a marker for prognosis of several tumor types. With the identification of the internalization of basigin-2 in response to antibody binding, we now further explore the possibility of its use as a dynamic portal of entry for …

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Cover Article: Carrageenan evoked P-Akt in deep dorsal horn neurons is prevented by loss of neurokinin1 positive neurons in superficial dorsal horn

Contributed by L.S. Sorkin, J.-I. Choi, and F.J. Koehrn, Univ. California San Diego, La Jolla, CA Paw inflammation with carrageenan elicits phosphorylation of Akt in spinal cord neurons with an unusual time course (Choi et al., 2010). Activation of Akt is seen first in neurons of the superficial dorsal horn and in α-motor neurons, followed …

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