tt2011

Cover Article: Targeted Toxins – Cheaper and Quicker than Knockouts

Cell-specific targeting and removal: cheaper and quicker than knockouts with high impact results. Knockout models are helpful tools in scientific research. They have been useful in studying and modeling in all sorts of research in biology; so much so that the pioneers – Smithies, Capecchi and Evans – won a well-deserved Nobel Prize for Physiology …

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Targeting Trends 2011 Newsletter

Read the 2011 Newsletters 2011, issue 1: Targeted Lesion of Caudal Brainstem Catecholamine Neurons Reveals Their Role in Symptoms of Fatigue / by Goehler LE, Gaykema RPA / featuring Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18) SFN Poster of the Year Targeting Talk: Time Course for Toxins, Custom Mouse IgM Conjugate and Controls, Destroy Hippocampal Neurons …

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Targeting Tools: Neurotensin Conjugates

Neurotensin is a 13 amino acid peptide found in the brain and spinal cord (first characterized by Carraway and Leeman1). It affects pituitary hormone release, interacts with the dopaminergic system, and is involved in vasodilation and hypotension. It can also modulate pain perception. Advanced Targeting Systems is pleased to announce two conjugates that will be …

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Targeting Topics 11q4

Galanin receptor-expressing dorsal horn neurons: Role in nociception. Lemons LL, Wiley RG. Neuropeptides Epub, August 2011. This work examines the nociceptive role of galanin receptor-1-expressing neurons found in the superficial dorsal horn. 500 ng of galanin-SAP (Cat. #IT-34) was injected into the lumbar intrathecal space of rats; blank-SAP (Cat. #IT-21) was used as a control. …

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Cover Article: Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity

Contributed by Tamara King and Frank Porreca Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA A common symptom of patients with neuropathic pain is spontaneous pain, often described as burning. Some patients also suffer from pain elicited by normally non-noxious stimuli, such as touch, referred to as allodynia. Preclinical studies have …

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Targeting Topics 11q3

BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration. Angelucci F, Gelfo F, Bartolo PD, Caltagirone C, Petrosini L. Neurochem Int 59(1):1-4, 2011. Brain-derived neurotrophic factor (BDNF) plays a role in neuronal function during the degeneration of neurons caused by pathological conditions such as Alzheimer’s disease. …

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Targeting Tools: FGF-2 Human Recombinant

Basic fibroblast growth factor (FGF-2) is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration …

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