We have re-designed the anti-murine p75-Saporin targeted toxin (mu p75-SAP, Cat. #IT-16) and have produced a conjugate that is much more potent in our in vitro cell cytotoxicity assays. Previously, we used a rat monoclonal antibody. This antibody had been outperformed by our rabbit polyclonal AB-N01, in several assays, especially FACS analysis of murine p75-expressing […]
Targeting Tools: mu p75-SAP Improved Read More »
Contributed by Dr. James Smith, Wake Forest University School of Medicine, Department of Physiology and Pharmacology, Medical Center Blvd, Winston-Salem NC 27157 Recent data implicate cholinergic neurons in the brain processes that underlie reinforcement. The involvement of cholinergic neurons in cocaine self-administration has been recently demonstrated using muscarinic and nicotinic agonists and antagonists, microdialysis, assessment
Advanced Targeting Systems is pleased to announce the availability of polyclonal antibodies to somatostatin receptor (SSTr) sub-types 1 and 4. SSTr1 antiserum, Cat. #AB-N19 SSTr1 affinity-purified, Cat. #AB-N20AP SSTr4 affinity-purified, Cat. #AB-N21AP Antibody to SSTr1 SSTr1 is a 391 amino acid G-protein-coupled receptor that contains three glycosylation sites and that is expressed in several areas
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Progress continues to be made in moving SP-SAP closer to clinical trials as a treatment for chronic pain. The latest development is the leasing of a 3700-sq ft facility adjacent to the current ATS facility in San Diego. This facility will be converted to GMP (Good Manufacturing Practice) space suitable for production of SP-SAP for
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Contributed by ATS’s 2003 Society for Neuroscience Poster of the Year Award Winner:Dr. Jill McGaughy, Boston University, 64 Cummington St., Boston, MA 02215 Muscarinic cholinergic receptor activation in entorhinal cortex (EC) activates intrinsic depolarizing membrane currents, which cause self-sustained spiking activity in single neurons.[1] This effect may underlie delay activity and match-dependent activity changes in
Awarded by ATS at Society for Neuroscience (SFN) New Orleans, Louisiana • November 8-12, 2003 Be sure to check out the cover article contributed by Dr. McGaughy in Targeting Trends newsletter (First Quarter, 2004). 425.4 CHOLINERGIC DEAFFERENTATION OF THE ENTORHINAL CORTEX IN RATS IMPAIRS ENCODING OF NOVEL BUT NOT FAMILIAR STIMULI IN A DELAYED NON-MATCH
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