tt2003

Targeting Trends 2003 Newsletter

Read the 2003 Newsletters 2003, issue 1: Deep Lumbar Neurons Control Ejaculation / by Truitt W / featuring SSP-SAP, Cat. #IT-11 SFN Poster of the Year SP-SAP as a Chronic Pain Therapeutic: An Update Targeting Talk: Custom Peptide-Saporin Conjugates Targeting Tools: Dermorphin-SAP (Cat. #IT-12) 2003, issue 2: Biotinylated targeting: A viable option? / featuring IB4-SAP (Cat. …

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Targeting Tools: Rat-ZAP

Advanced Targeting Systems is pleased to announce the arrival of its newest second immunotoxin, Rat-ZAP (Cat. #IT-26). This new screening agent is constructed from goat anti-rat IgG conjugated to saporin. Like the other second immunotoxins, Hum-ZAP, Mab-ZAP and Rab-ZAP, it converts your primary antibody, in this case a rat IgG, into a potent cytotoxic agent …

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Targeting Article: CCK-SAP in Binding Studies

Our thanks to Drs. Frank Porecca, Victory Hruby and Josephine Lai, Department of Pharmacology, The University of Arizona Health Sciences Center for sharing the results of their studies. Cholecystokinin (CCK) is widely distributed in the central nervous system and the gastrointestinal tract. The 33-amino acid peptide contains a carboxyl terminal octapeptide sequence Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 which confers …

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Targeting Topics 03q4

Hilar neuropeptide Y interneuron loss in the aged rat hippocampal formation. Cadacio CL, Milner TA, Gallagher M, Pierce JP. Exp Neurol 183(1):147-158, 2003. The authors investigate the loss of neuropeptide Y-immunoreactive (NPY-I) interneurons in the dentate gyrus of aged rats. Their results show a loss of a select group of interneurons in these animals. The …

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Cover Article: Subplate Neurons and Functional Maturation of Thalamocortical Synapses

Contributed by Dr. Patrick O. Kanold, Dept Neurobiology, Harvard Medical School, Boston, MA 02115.Dr. Kanold summarizes his work with ME20.4-SAP. A complete report was published in Science 301:521-525. The processing of information in the visual system happens in multiple stages. Retinal neurons in the eye connect to neurons in the lateral geniculate nucleus (LGN), that …

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Targeting Tools: Targeting the Dopamine Transporter

Advanced Targeting Systems announces the availability of two monoclonal antibodies to the dopamine transporter (DAT). These antibodies have become a standard for work on DAT and have already played a prominent role in the characterization of the dopamine transporter. The two antibodies are rat monoclonals, so they can be excellent for multiple staining protocols. Anti-DAT-NT, Cat. …

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Targeting Topics 03q3

Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli. Vierck CJJ, Kline RH, Wiley RG. Neuroscience 119(1):223-232, 2003. Administration of SP-SAP (Cat. #IT-07) eliminates sensitization of nocifensive reflexes. The authors investigate whether SP-SAP elimination of neurokinin-1 receptor-expressing neurons in the lumbar spinal cord affects nociceptive sensitivity in general, or preferentially affects nociception dependent on …

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Cover Article: A New Immunotoxin for Targeting Dopaminergic Neurons

Targeting results with anti-DAT-SAP (Cat. #IT-25) shown in Figure 1 are reprinted by permission of Kluwer Academic/Plenum Publishers. The original was published in Cell Mol Neurobiol 23:839-850, 2003. Dopaminergic neurons are widely studied because of their role in one of the devastating diseases of old age, Parkinson’s. Lesioning studies using 6-hydroxydopamine or MPTP have been …

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