tt2003

Targeting Tools: Rat-ZAP

Advanced Targeting Systems is pleased to announce the arrival of its newest second immunotoxin, Rat-ZAP (Cat. #IT-26). This new screening agent is constructed from goat anti-rat IgG conjugated to saporin. Like the other second immunotoxins, Hum-ZAP, Mab-ZAP and Rab-ZAP, it converts your primary antibody, in this case a rat IgG, into a potent cytotoxic agent …

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Targeting Article: CCK-SAP in Binding Studies

Our thanks to Drs. Frank Porecca, Victory Hruby and Josephine Lai, Department of Pharmacology, The University of Arizona Health Sciences Center for sharing the results of their studies. Cholecystokinin (CCK) is widely distributed in the central nervous system and the gastrointestinal tract. The 33-amino acid peptide contains a carboxyl terminal octapeptide sequence Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 which confers …

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ATS Receives $2.4 M Award for SP-SAP Drug Development

ATS has received a Small Business Innovation Research (SBIR) grant from the National Institute of Mental Health (NIMH) under the program announcement for competing continuation awards for pharmacologic agents and drugs for mental disorders. This three-year, $2.4 million award is a continuation of Phase II funding for the development of a drug for the treatment …

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Cover Article: Subplate Neurons and Functional Maturation of Thalamocortical Synapses

Contributed by Dr. Patrick O. Kanold, Dept Neurobiology, Harvard Medical School, Boston, MA 02115.Dr. Kanold summarizes his work with ME20.4-SAP. A complete report was published in Science 301:521-525. The processing of information in the visual system happens in multiple stages. Retinal neurons in the eye connect to neurons in the lateral geniculate nucleus (LGN), that …

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Targeting Tools: Targeting the Dopamine Transporter

Advanced Targeting Systems announces the availability of two monoclonal antibodies to the dopamine transporter (DAT). These antibodies have become a standard for work on DAT and have already played a prominent role in the characterization of the dopamine transporter. The two antibodies are rat monoclonals, so they can be excellent for multiple staining protocols. Anti-DAT-NT, Cat. …

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Substance P-Saporin (SP-SAP) Drug Development Update

Substance P-Saporin (SP-SAP) is under development as a chronic pain therapeutic with tremendous potential to permanently eliminate suffering in many painful diseases and conditions. ATS is awaiting news from the National Institutes of Health on further funding to fulfill FDA requirements to bring SP-SAP to clinical trial in humans. ATS has a patent on SP-SAP …

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Cover Article: A New Immunotoxin for Targeting Dopaminergic Neurons

Dopaminergic neurons are widely studied because of their role in one of the devastating diseases of old age, Parkinson’s. Lesioning studies using 6-hydroxydopamine or MPTP have been useful in research on Parkinson’s Disease. However, these reagents have limitations such as MPTP affecting catecholaminergic neurons and 6-OHDA stability and specificity issues. Targeting dopaminergic neurons with an …

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Funding Awarded for SBIR Phase II Grant

On February 1, 2003 ATS was awarded an $800,000 grant from the National Institutes of Health, National Institute of Mental Health. This three-year grant will support the creation of monoclonal antibodies to the extracellular domains of G protein-coupled receptors. These receptors play an important role in all aspects of human health, reflecting their widespread presence …

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