16q2

Targeting Trends 2016 Newsletter

2016, issue 1: Striatal patch compartment lesions reduce cocaine-induced repetitive behaviors / by KA Horner and collaborators R Murray and MC Logan Mercer / featuring Dermorphin-SAP (Cat. #IT-12) From the President: New Beginnings Targeting Talk: Safety of the Toxin Featured Products: Custom Conjugates 2016, issue 2: Cerebral cholinergic lesion reduces operant responses to unpleasant thermal …

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Kermit Judges from on High

For years ATS customers have been Gangsta and Kermit fans, and now it is time to show your love by adding a caption to Kermit’s picture!  Each quarter we will post a picture of Kermit up to his usual hijinks and ask our readership to offer their most creative captions.  Be clever and creative as Kermit …

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Targeting Talk: Saporin Safety

Over the years, ATS has frequently been asked about Saporin’s safety for use in the lab as well as when used clinically. Residual awareness of alternate Ribosome-Inactivating Proteins (RIPs) and ‘toxins’ such as Ricin have caused some researchers new to the use of RIPs to question the belief that Saporin is safe.  Unlike Type 2 …

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Targeting Topics 16q2

The peptidergic control circuit for sighing. Li P, Janczewski WA, Yackle K, Kam K, Pagliardini S, Krasnow MA, Feldman JL. Nature 530(7590):293-297, 2016. PMID: 26855425 Sighs are often associated with relief or sadness, but rodents sigh spontaneously dozens of times per hour. There are physiological benefits to sighing, including enhancement of gas exchange and preservation …

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Toolbox: vGAT Products

ATS is pleased to present a new product line specific for the vesicular GABA transporter (vGAT) protein. vGAT mediates both the accumulaXon of GABA into synaptic vesicles and its release from nerve terminals. vGAT is expressed in nerve endings of GABAergic neurons throughout the CNS. The GABAergic system is crucial to the development and functional …

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From the President: A Sigh is (Not) Just a Sigh . . .

The fundamental things apply. “The Peptidergic Control Circuit for Sighing,” recently published in the prestigious journal Nature, has made us rethink our fundamental belief that sighs are only “long, deep breaths expressing sadness, relief or exhaustion.” Often prompting someone to say, “What’s wrong?” As it turns out, sighs “also occur spontaneously every few minutes to …

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Cover Article: Cerebral cholinergic lesion reduces operant responses to unpleasant thermal stimuli

by Ronald G. Wiley, M.D., Ph.D., Departments of Neurology and Pharmacology, Vanderbilt University, Nashville, TN  and C. J. Vierck, Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, USA Degeneration of the cholinergic basal forebrain (CBF: medial septum, diagonal band of Broca, nucleus basalis of Meynert/substantia innominata) is a prominent …

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