Read the 2014 Newsletters and recent scientific references 2014, issue 1: FDA Gives Green Light to Human Clinical Trials for Cancer Pain / by DA Lappi / featuring SP-SAP Targeting Talk: Time Course Targeting Tools: Investigating the Itch Pathway 2014, issue 2: Celebrating Twenty Years of Science Advanced Targeting Systems (founded 22 Apr 1994) / featuring 192-IgG-SAP, SP-SAP, Bombesin-SAP …
Top Five Targeted Toxins #1. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) targets cells expressing rat p75NTR #2. Anti-DBH-SAP (Cat. #IT-03) targets cells expressing rat dopamine beta-hydroxylase (DBH) #3. mu p75-SAP (Cat. #IT-16) targets cells expressing mouse p75NTR #4. IB4-SAP (Cat. #IT-10) targets cells expressing α-D-galactopyranoside residues #5. Mac-1-SAP mouse/human (Cat. #IT-06) targets cells expressing mouse / human …
2000 – Robert Sloviter and Jennifer Martin used SSP-SAP (Cat# IT-11) 2001 – Mary Ann Greco used Orexin-SAP 2002 – Lique Coolen and William Truitt used SSP-SAP (Cat# IT-11) 2003 – Jill McGaughy used 192-IgG-Saporin (Cat# IT-01) 2004 – Michelle Pearson used IB4-SAP (Cat# IT-10) 2005 – W.Zhang used Dermorphin-SAP (Cat. #IT-12) and CCK-SAP (Cat. #IT-31) 2006 – Neelima Chauhan used mu …
Advanced Targeting Systems’ first product, 192-IgG-SAP, answered a long-sought request from behavioral neuroscientists: a neurotoxin for the cholinergic neurons of the basal forebrain. Over the years it has become the classic in the field and has changed the way that we think about those neurons and their role in learning and memory. Substance P-saporin (SP-SAP) …
Kilgard MP, Merzenich MM. (1998) Cortical map reorganization enabled by nucleus basalis activity. Science 279(5357):1714-1718. (Cat. #IT-01) – 888 citations Lu J, Sherman D, Devor M, Saper CB. (2006) A putative flip-flop switch for control of REM sleep. Nature 441(7093):589-594. (Cat. #IT-20) – 494 citations Mantyh PW, Rogers SD, Honore P, Allen BJ, Ghilardi JR, …