SP-CTA (Cat. #IT-39) is an exciting new tool for use in the research of neurokinin (NK-1) receptor-expressing cells of the central nervous system. A conjugate of the substance P molecule and the catalytic subunit of Cholera toxin, this product can be used very effectively in vivo for increasing sensitization of these neuronal cells. Selectively targeting …
Species Reactivity: Human, Rat, Mouse, Rabbit Anti-AChR (Cat. #AB-N36) binds with high affinity to the AChR subtype with 59 kDa ACh-binding subunits, but with considerably lower affinity to the AChR subtype with 75 kDa subunits. Anti-AChR binds to the main immunogenic region on α1 subunits of muscle-type AChRs. Reference 1. Schoepfer R, Halvorsen SW, Conroy …
FGF-2, or basic fibroblast growth factor, binds all of the FGF receptors with high affinity. We have used this molecule to produce FGF-SAP (Cat. #IT-38), which has a healthy experimental publication record (“FGF” and “saporin” in PubMed: 25 hits). It has been used to clean primary cultures of fibroblasts.[1] It was important in determining the …
2007, issue 1: Cholinergic Immunolesioning Produced Tangle-like Inclusions in TgCRND8 Brain / by Chauhan N / featuring mu p75-SAP (Cat. #IT-16) SFN Poster of the Year Targeting Talk: Targeted Toxin Controls Targeting Tools Anti-Pseudomonas aeurginosa (Cat. #AB-T057) Anti-Conjugated Glutathione (Cat. #AB-T01) Anti-Conjugated Acetylcholine (Cat. #AB-T02) Anti-Conjugated Dopamine (Cat. #AB-T11) Anti-CRH/CRF (Cat. #AB-02) Anti-basic FGF (Cat. #AB-07, Cat. #AB-08) …
Can you tell me how I would calculate the amount of a SAP-type targeted toxin that I might want to buy based on a desire to bilaterally kill cells of interest within a typical diffusion zone around an injection site in a rodent brain? Use CRF-SAP (Cat. #IT-13) as an example. Are we talking a …
Cortical cholinergic deficiency enhances amphetamine-induced dopamine release in the accumbens but not in the striatum Mattsson A, Olson L, Svensson TH, Schilstrom B Exp Neurol 208(1):73-79, 2007. Previous data have implicated cholinergic dysfunction in the pathogenesis of schizophrenia. Here the authors investigated whether increased amphetamine-induced release of dopamine was a response to cortical cholinergic denervation. …
Contributed by Robert M. Caudle, Ph.D.University of Florida College of Dentistry, Gainesville, FL 32610 A substantial amount of work with Advanced Targeting Systems’ substance P/saporin conjugate (SP-SAP, Cat. #IT-07) has demonstrated that neurokinin-1 (NK1) receptor-expressing neurons in the spinal cord and brain stem are necessary for the full expression of central sensitization following a peripheral …