07q2

Targeting Trends 2007 Newsletter

Read the 2007 Newsletters 2007, issue 1: Cholinergic Immunolesioning Produced Tangle-like Inclusions in TgCRND8 Brain / by Chauhan N / featuring mu p75-SAP (Cat. #IT-16) SFN Poster of the Year Targeting Talk: Targeted Toxin Controls Targeting Tools Anti-Pseudomonas aeurginosa (Cat. #AB-T057) Anti-Conjugated Glutathione (Cat. #AB-T01) Anti-Conjugated Acetylcholine (Cat. #AB-T02) Anti-Conjugated Dopamine (Cat. #AB-T11) Anti-CRH/CRF (Cat. #AB-02) Anti-basic …

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New Targets: Insula Receptors

In the January 26 issue of Science there was an article by Naqvi et al. about patients with brain damage to the insula losing their desire to smoke. A podcast interview with Dr. Bechara, one of the authors of the study, ended with him stating that there are a number of known receptors in the brain that should be …

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Targeting Tools: Goat-ZAP

Goat-ZAP (Cat. #IT-36) is a new secondary conjugate of affinity-purified rabbit anti-goat IgG and the ribosome-inactivating protein, saporin. This product uses affinity-purified rabbit anti-goat IgG to “piggyback” onto YOUR primary goat antibody in order to evaluate the ability of your primary antibody to internalize. Once the conjugate is internalized, saporin breaks away from the targeting …

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Targeting Tools: Fluorescent Conjugates

ATS has added three new products to our fluorescent conjugates line. Alexa488-labeled affinity purified NGFr* (Cat. #FL-N01AP) FITC-labeled Goat Anti-Rat IgG (Cat. #FL-10) FITC-labeled Donkey Anti-Goat IgG (Cat. #FL-11) *(Cat. #AB-N01AP) These conjugates are excellent tools to verify specific binding to an antigen. By first incubating cells with the primary antibody, and then binding the …

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Targeting Topics 07q2

Cholinergic modulation of sensory interference in rat primary somatosensory cortical neurons Alenda A, Nunez A Brain Res 1133(1):158-167, 2007. One critical feature of cognition is the ability to focus on selected sensory inputs while ignoring irrelevant inputs. In this work the authors examine basal forebrain participation in sensory interference effects. Following 0.15 µg bilateral injections …

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SP-SAP Drug Development Update

Substance P-Saporin (SP-SAP) is a drug candidate that eliminates the spinal cord neurons that send the chronic pain signal to the brain. SP-SAP has been tested in a variety of animal models and proven effective in permanently eliminating the perception of chronic pain. ATS has completed extensive preclinical studies, a GLP toxicology study, and a …

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Cover Article: Nucleus tractus solitarii injections of substance P-conjugated saporin selectively disrupts baroflex-dependent pathways.

Contributed by Jeffrey T. Potts, Ph.D., Department of Biomedical Science, College of Veterinary Medicine, Dalton Cardiovascular Research Center, Columbia, MO 65211 The nucleus tractus solitarii (NTS) receives afferent input from visceral, somatic and cardiopulmonary structures and is the first central site for the processing of these sensory autonomic signals. Modulation of sensory neurotransmission has been well …

Cover Article: Nucleus tractus solitarii injections of substance P-conjugated saporin selectively disrupts baroflex-dependent pathways. Read More »