04q2

Targeting Trends 2004 Newsletter

Read the 2004 Newsletters and recent scientific references 2004, issue 1: Cholinergic Deafferentation of the Entorhinal Cortex Impairs Working Memory for Novel, but not Familiar Stimuli in a Delayed Non-Match to Sample (DNMS) Task / by McGaughy J / featuring 192-IgG-SAP (Cat. #IT-01) ATS Gets New Facility for SP-SAP Production SFN Poster of the Year …

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Targeting Tools: mu p75-SAP Improved

We have re-designed the anti-murine p75-Saporin targeted toxin (mu p75-SAP, Cat. #IT-16) and have produced a conjugate that is much more potent in our in vitro cell cytotoxicity assays. Previously, we used a rat monoclonal antibody. This antibody had been outperformed by our rabbit polyclonal AB-N01, in several assays, especially FACS analysis of murine p75-expressing …

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Targeting Tools: Anti-Tac (CD25)-SAP

Advanced Targeting Systems has introduced important new toxins for investigation into cells that express the interleukin-2 (IL-2) receptor and especially the workings of the immune system. Anti-CD25-saporin (Anti-Tac-SAP) conjugates are directed to the human IL-2 receptor or to the mouse IL-2 receptor. This marker for activated T lymphocytes allows removal of this important group of …

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Cover Article: 192 IgG-Saporin-Induced Lesions Identify an Inhibitory Role in Cocaine Reward for Cholinergic Neuronal Systems in the Diagonal Band and Ventral Pallidum

Contributed by Dr. James Smith, Wake Forest University School of Medicine, Department of Physiology and Pharmacology, Medical Center Blvd, Winston-Salem NC 27157 Recent data implicate cholinergic neurons in the brain processes that underlie reinforcement. The involvement of cholinergic neurons in cocaine self-administration has been recently demonstrated using muscarinic and nicotinic agonists and antagonists, microdialysis, assessment …

Cover Article: 192 IgG-Saporin-Induced Lesions Identify an Inhibitory Role in Cocaine Reward for Cholinergic Neuronal Systems in the Diagonal Band and Ventral Pallidum Read More »