a chemical conjugate of avidin and the ribosome-inactivating protein, saporin Avidin is a glycoprotein found in egg white and in tissues of birds, reptiles, and amphibians. This protein is composed of four subunits, each of which can bind one molecule of biotin. Biotin, a 244-dalton vitamin found in tissue and blood, binds with high affinity to […]
Targeting Tools: Avidinylated SAP Read More »
On February 1, 2003 ATS was awarded an $800,000 grant from the National Institutes of Health, National Institute of Mental Health. This three-year grant will support the creation of monoclonal antibodies to the extracellular domains of G protein-coupled receptors. These receptors play an important role in all aspects of human health, reflecting their widespread presence
Funding Awarded for SBIR Phase II Grant Read More »
For the IB4-SAP (Cat. #IT-10) illustration (Figure 1), our thanks to Christopher N. Honda, Ph.D., Associate Professor, Department of Neuroscience, University ofMinnesota, 6-145 Jackson Hall, 321 Church Street, Minneapolis, MN 55455 This issue of our quarterly newsletter addresses the use of biotinylated materials in targeting. ATS is now offering a biotinylation service (see p. 7)
Cover Article: Biotinylated targeting. A viable option? Read More »
Even though it only became available recently, Dermorphin-SAP (Cat. #IT-12) has already begun to help researchers unlock the mysteries of brain function. Dermorphin-SAP is a chemical conjugate between an analog of the frog skin peptide dermorphin and the ribosome- inactivating protein saporin. Dermorphin, a peptide of seven amino acids characterized by Ersparmer and his colleagues,1
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Advanced Targeting Systems continues to search for funding to develop Substance P-Saporin (SP-SAP) as a chronic pain therapeutic. In May of last year we decided to seek venture capital funding and began traveling to make presentations to potential investors. The response from most everyone we spoke to was positive and they thought the potential of
SP-SAP as a Chronic Pain Therapeutic: An Update Read More »
Contributed by William Truitt, PhD, Department of Cell Biology, Neurobiology, and Anatomy, Neuroscience Graduate Program, University of Cincinnati, College of Medicine, Post Office Box 670521, Cincinnati, OH 45267-0521, USA. Previously we demonstrated the existence of a spinothalamic pathway in the male rat where neural activation is specifically induced by ejaculation.1 This pathway includes the parvocellular
Cover Article: Deep Lumbar Neurons Control Ejaculation Read More »
Read the 2002 Newsletters and receint scientific references 2002, issue 1: Control Conjugates: The Perfect Companion for Targeted Toxins / by Lappi DA / featuring Control Conjugates SFN Poster of the Year Targeting Talk: Toxin Safety Targeting Tools: Serotonin Transporter Antibody 2002, issue 2: HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not / by Blanco-Centurion
Targeting Trends 2002 Newsletter Read More »
Awarded by ATS at Society for Neuroscience (SFN) Orlando, FL • November 3-6, 2002 Be sure to check out the cover article in our Targeting Trends newsletter (First Quarter, 2003). 69.2 LESIONS OF SPINOTHALAMIC NEURONS IN LUMBAR SPINAL CORD DISRUPT EJACULATORY REFLEXES IN MALE RATS. WA Truitt; KE McKenna; LM Coolen featuring IT-11 SSP-SAP (Poster)
SFN Poster of the Year 2002 Read More »
Contributed by Jean-Christophe Cassel, PhD, Laboratoire de Neurosciences Cognitives et Comportementales, UMR 7521 Université Louis Pasteur/CNRS, Strasbourg, France & Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Freiburg, Germany. Dr. Cassel and colleagues are the authors of four publications released this quarter using 192-Saporin (Cat. #IT-01) Trying to understand how
Cover Article: Does 192-IgG-Saporin or 5,7-DHT kill cognitive functions in the rat? Read More »