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Activation of the renin-angiotensin system in high fructose-induced metabolic syndrome.
Kim M, Do GY, Kim I (2020) Activation of the renin-angiotensin system in high fructose-induced metabolic syndrome. Korean J Physiol Pharmacol 24(4):319-328. doi: 10.4196/kjpp.2020.24.4.319 PMID: 32587126
Objective: To investigate the hypothesis that high fructose intake induces activation of the renin-angiotensin systems (RAS), resulting in hypertension and metabolic syndrome.
Summary: High fructose intake increased serum renin, Ang II, triglyceride, and cholesterol levels. High fructose intake increased the expression of angiotensinogen in the liver; angiotensin-converting enzyme in the lungs; and renin, angiotensin II type 1a receptor (AT1aR), and angiotensin II type 1b receptor (AT1bR) in the kidneys. High fructose intake induces activation of RAS, resulting in hypertension and metabolic syndrome.
Usage: Immunohistochemistry
Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)
Integration of peripheral and central systems in control of ingestive and reproductive behavior
Schneider J (2020) Integration of peripheral and central systems in control of ingestive and reproductive behavior. Oxford Research Encyclopedia of Neuroscience . Oxford University Press doi: 10.1093/acrefore/9780190264086.013.23
Summary: Highly glucose-sensitive cells in the ventrolateral medulla send catecholaminergic projections to the PVH. These projections can be selectively destroyed by Anti-DBH-SAP “DSAP” experiments show that catecholaminergic projections from glucose-sensitive cells in the ventrolateral medulla are necessary for all responses to glucoprivation, including increases in epinephrine secretion, glucocorticoid secretion, sex behavior, and food intake.
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Increased expression of connexin 43 in a mouse model of spinal motoneuronal loss
Spitale FM, Vicario N, Rosa MD, Tibullo D, Vecchio M, Gulino R, Parenti R (2020) Increased expression of connexin 43 in a mouse model of spinal motoneuronal loss. Aging (Albany NY) 12(13):12598-12608. doi: 10.18632/aging.103561 PMID: 32579130
Objective: To investigate the role of the main astroglial gap junctions (GJs)-forming connexin, Cx43, in human Amyotrophic lateral sclerosis (ALS) and the effects of focal spinal cord motoneuronal depletion onto the resident glial cells and Cx43 levels.
Summary: The data support the hypothesis that motoneuronal depletion may affect glial activity, which in turn results in reactive Cx43 expression, further promoting neuronal suffering and degeneration.
Usage: 12 μg of CTB-SAP injected into the left gastrocnemius muscle of mice to establish a model of spinal motoneuronal depletion.
Related Products: CTB-SAP (Cat. #IT-14)
Exaggerated postnatal surge of orexin and the effects of elimination of excess orexin on blood pressure in spontaneously hypertensive rats in postnatal development
Barnett S, Dong R, Briggs L, Moushey A, Li A (2020) Exaggerated postnatal surge of orexin and the effects of elimination of excess orexin on blood pressure in spontaneously hypertensive rats in postnatal development. bioRxiv 2020.06.17.158279. doi: 10.1101/2020.06.17.158279
Related Products: Orexin-B-SAP (Cat. #IT-20)
Central circuit mechanisms of itch.
Chen XJ, Sun YG (2020) Central circuit mechanisms of itch. Nat Commun 11:3052. doi: 10.1038/s41467-020-16859-5
Summary: The authors summarize the progress in elucidating the neural circuit mechanism of itch at spinal and supraspinal levels.
Related Products: SSP-SAP (Cat. #IT-11)
Identification of multiple targets in the fight against Alzheimer’s disease
Giannoni P, Fossati S, Claeysen S, Marcello E, eds (2020) Identification of multiple targets in the fight against Alzheimer’s disease. Front Aging Neurosci 12:169. doi: 10.3389/fnagi.2020.00169
Summary: A collection of 20 articles that depict a broad representation of the most impactful advances in Alzheimer’s disease (AD) comprehension and therapeutic openings.
Related Products: 192-IgG-SAP (Cat. #IT-01), mu p75-SAP (Cat. #IT-16)
GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn.
Kiguchi N, Uta D, Ding H, Uchida H, Saika F, Matsuzaki S, Fukazawa Y, Abe M, Sakimura K, Ko MC, Kishioka S (2020) GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn. Neuropharmacology 170:108025. doi: 10.1016/j.neuropharm.2020.108025
Objective: To investigate the mechanisms for the activation of itch-responsive GRPR+ neurons in the spinal dorsal horn (SDH).
Summary: These findings demonstrate that GRP and glutamate cooperatively regulate GRPR+ AMPAR+ neurons in SDH, mediating itch sensation. GRP–GRPR and the glutamate–AMPAR system may play pivotal roles in the spinal transmission of itch in rodents and nonhuman primates.
Usage: Bombesin-SAP and Blank-SAP were administered i.t. (5 μg/5 μl).
Related Products: Bombesin-SAP (Cat. #IT-40), Blank-SAP (Cat. #IT-21)
Inhibition of ROCK signaling pathway accelerates enteric neural crest cell-based therapy after transplantation in a rat hypoganglionic model
Zhao Y, Ge X, Yu H, Kuil LE, Alves MM, Tian D, Huang Q, Chen X, Hofstra RMW, Gao Y (2020) Inhibition of ROCK signaling pathway accelerates enteric neural crest cell-based therapy after transplantation in a rat hypoganglionic model. Neurogastroenterol Motil 32(9):e13895. doi: 10.1111/nmo.13895 PMID: 32515097
Objective: To test the hypothesis that modulation of extracellular factors during transplantation could promote enteric neural crest cells (ENCCs) proliferation and migration, leading to increased transplantation efficiency.
Summary: Since the RhoA/ROCK pathway is highly involved in cytoskeletal dynamics and neurite growth, this study explored the effect of inhibition of this pathway to improve the success of ENCCs transplantation. inhibition of ROCK increased viable cell number, differentiation, and migration of ENCCs in vitro. Moreover, transplantation of labeled ENCCs into the hypoganglionic model showed enhanced distribution of grafted ENCCs, upon treatment with ROCK inhibitor.
Usage: Immunofluorescence (1:200); AB-N01AP: NGFr (mu p75) Rabbit Polyclonal
Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)
A common neuronal mechanism of hypertension and sleep disturbances in spontaneously hypertensive rats: Role of orexinergic neurons.
Cui S-Y, Huang Y-L, Cui X-Y, Zhao H-L, Hu X, Liu Y-T, Qin Y, Kurban N, Zhang Y-H (2020) A common neuronal mechanism of hypertension and sleep disturbances in spontaneously hypertensive rats: Role of orexinergic neurons. Prog Neuropsychopharmacol Biol Psychiatry 100:109902. doi: 10.1016/j.pnpbp.2020.109902
Objective: To investigate dynamic changes in sleep patterns during the development of hypertension.
Summary: Although the correlation between sleep disturbances and hypertension is very complex, common mechanisms may underlie these comorbidities.
Usage: Orexin-B-SAP (HCRT2-SAP) was administered in two injections/side (100 and 200 ng/0.5 μl/injection).
Related Products: Orexin-B-SAP (Cat. #IT-20)
A versatile cholera toxin conjugate for neuronal targeting and tracing
Haigh JL , Williamson DJ , Poole E , Guo Y , Zhou D , Webb ME , Deuchars SA , Deuchars J , Turnbull WB (2020) A versatile cholera toxin conjugate for neuronal targeting and tracing. Chem Commun (Camb) 56(45:6098-6101. doi: 10.1039/d0cc01085e PMID: 32355935
Related Products: Cholera Toxin B, Recombinant (Cat. #PR-14)