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  4. Disruption of basal forebrain cholinergic neurons after traumatic brain injury does not compromise environmental enrichment-mediated cognitive benefits.

Disruption of basal forebrain cholinergic neurons after traumatic brain injury does not compromise environmental enrichment-mediated cognitive benefits.

Moschonas EH, Leary JB, Memarzadeh K, Bou-Abboud CE, Folweiler KA, Monaco CM, Bondi CO (2021) Disruption of basal forebrain cholinergic neurons after traumatic brain injury does not compromise environmental enrichment-mediated cognitive benefits. Brain Res 1751:147175. doi: 10.1016/j.brainres.2020.147175

Objective: To determine if basal forebrain cholinergic neurons are important mediators of environmental enrichment (EE)-induced benefits after traumatic brain injury.

Summary: These data show that despite significant medial septal ChAT+ cell loss, the EE-mediated benefit in cognitive recovery is not compromised.

Usage: 0.22 μg/1.0 μL 192-IgG-SAP was infused over 5 min at a rate of 0.2 μL/min.

Related Products: 192-IgG-SAP (Cat. #IT-01)