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B fragment of cholera toxin conjugated to saporin
Ohara PT, Kelley K, Jasmin L (2005) B fragment of cholera toxin conjugated to saporin . (eds. Ronald GW, Douglas AL). Molecular Neruosurgery With Targeted Toxins 293-306. Humana. doi: 10.1007/978-1-59259-896-0_13
Summary: CTB-Saporin is a lesioning tool used to target GM1 ganglioside residues, which are highly expressed within certain nervous cell tissue. It distinguishes itself from other common saporin conjugates as it is most used not to lesion neurons but instead mylelin producing oligodendrocytes. CTB-SAP can be used to target these cells in order to study demyelination and remyelination in the spinal cord.
Related Products: CTB-SAP (Cat. #IT-14)
Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release.
Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL (2005) Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. J Neurosci 25(14):3651-3660. doi: 10.1523/JNEUROSCI.0252-05.2005 PMID: 15814796
Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)
Featured Article: Noradrenergic inputs to the medial amygdala originate in the A1 and A2 cells groups and release norepinephrine after mating stimulation sufficient to induce pseudopregnancy
Northrop LE, Cameron N, Erskine M (2005) Featured Article: Noradrenergic inputs to the medial amygdala originate in the A1 and A2 cells groups and release norepinephrine after mating stimulation sufficient to induce pseudopregnancy. Targeting Trends 6(2)
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Hereditary ferritinopathy: a novel mutation, its cellular pathology, and pathogenetic insights
Mancuso M, Davidzon G, Kurlan RM, Tawil R, Bonilla E, Di Mauro S, Powers JM (2005) Hereditary ferritinopathy: a novel mutation, its cellular pathology, and pathogenetic insights. J Neuropathol Exp Neurol 64(4):280-294. doi: 10.1093/jnen/64.4.280 PMID: 15835264
Related Products: Malondialdehyde Rabbit Polyclonal, Conjugated (Cat. #AB-T090)
Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine.
Mothet JP, Pollegioni L, Ouanounou G, Martineau M, Fossier P, Baux G (2005) Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine. Proc Natl Acad Sci U S A 102(15):5606-5611. doi: 10.1073/pnas.0408483102 PMID: 15800046
Related Products: D-Serine Rabbit Polyclonal, Conjugated (Cat. #AB-T048)
Acetylcholine in the orbitofrontal cortex is necessary for the acquisition of a socially transmitted food preference.
Ross RS, McGaughy J, Eichenbaum H (2005) Acetylcholine in the orbitofrontal cortex is necessary for the acquisition of a socially transmitted food preference. Learn Mem 12(3):302-306. doi: 10.1101/lm.91605
Summary: Cortical involvement in social transmission of food preference (STFP) has not been established, but the importance of the orbitofrontal cortex (OFC) in odor-guided learning is known. The OFC of rats was injected twice with 192-Saporin (Cat. #IT-01), then the rats were trained in STFP. Depletion of cholinergic neurons in the OFC impaired expression of the odor association, indicating that cholinergic function in the OFC is essential for this form of associative learning.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Fluorescent tagging of rhythmically active respiratory neurons within the pre-Bötzinger complex of rat medullary slice preparations.
Pagliardini S, Adachi T, Ren J, Funk GD, Greer JJ (2005) Fluorescent tagging of rhythmically active respiratory neurons within the pre-Bötzinger complex of rat medullary slice preparations. J Neurosci 25:2591-2596. doi: 10.1523/JNEUROSCI.4930-04.2005 PMID: 15758169
Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)
Impairment of skilled forelimb use after ablation of striatal interneurons expressing substance P receptors in rats: an analysis using a pasta matrix reaching task.
Chiken S, Tokuno H (2005) Impairment of skilled forelimb use after ablation of striatal interneurons expressing substance P receptors in rats: an analysis using a pasta matrix reaching task. Exp Brain Res 162(4):532-536. doi: 10.1007/s00221-004-2189-2
Summary: The substance P receptor is expressed by two types of interneurons in the striatum. The authors investigated whether elimination of these neurons would impair motor control by the basal ganglia. Rats were treated with 7.5 ng injections of SP-SAP (Cat. #IT-07) into the dorsolateral part of the striatum. Lesioned animals did not perform as well as controls in a test measuring accurate reaching with the forepaw. The data show that striatal interneurons expressing the substance P receptor are necessary for accurate reaching.
Related Products: SP-SAP (Cat. #IT-07)
Impairments in working memory and decision-taking processes in monkeys in a model of Alzheimer’s disease.
Dudkin KN, Chueva V, Makarov FN, Bich TG, Roer AE (2005) Impairments in working memory and decision-taking processes in monkeys in a model of Alzheimer’s disease. Neurosci Behav Physiol 35(3):281-289. PMID: 15875490
Related Products: ME20.4-SAP (Cat. #IT-15), Anti-DBH-SAP (Cat. #IT-03)
Basomedial hypothalamic injections of neuropeptide Y conjugated to saporin selectively disrupt hypothalamic controls of food intake.
Bugarith K, Dinh TT, Li AJ, Speth RC, Ritter S (2005) Basomedial hypothalamic injections of neuropeptide Y conjugated to saporin selectively disrupt hypothalamic controls of food intake. Endocrinology 146(3):1179-1191. doi: 10.1210/en.2004-1166
Summary: The authors examined the effect of 48 ng injections of NPY-SAP (Cat. #IT-28) into the basomedial hypothalamus (BMH) on glucoprivic feeding in rats. While there was no evidence of retrograde transport, the lesions inhibited responses to intracerebroventricular leptin and ghrelin. Neither the feeding nor the hyperglycemic response to 2-deoxy-D-glucose was affected by the lesion, indicating that these hindbrain processes do not utilize neurons in the BMH. This work also describes dosing and injection parameter studies for the use of NPY-SAP.
Related Products: NPY-SAP (Cat. #IT-28), Blank-SAP (Cat. #IT-21)