Chiken S, Tokuno H (2005) Impairment of skilled forelimb use after ablation of striatal interneurons expressing substance P receptors in rats: an analysis using a pasta matrix reaching task. Exp Brain Res 162(4):532-536. doi: 10.1007/s00221-004-2189-2
Summary: The substance P receptor is expressed by two types of interneurons in the striatum. The authors investigated whether elimination of these neurons would impair motor control by the basal ganglia. Rats were treated with 7.5 ng injections of SP-SAP (Cat. #IT-07) into the dorsolateral part of the striatum. Lesioned animals did not perform as well as controls in a test measuring accurate reaching with the forepaw. The data show that striatal interneurons expressing the substance P receptor are necessary for accurate reaching.
Related Products: SP-SAP (Cat. #IT-07)