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One of the most important features of the Advanced Targeting Systems product line is the availability of control toxins that allow the researcher to fully evaluate results of the treatment of cells or animals with targeted toxins. For instance, anti-DBH-SAP is targeted with a mouse monoclonal antibody. Its control partner is mouse IgG-SAP, that is, […]

ATS is pleased to present a polyclonal antibody specific for ChAT protein. Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both the peripheral and central nervous systems. Dysfunction of cholinergic neurons underlies aspects of clinical

CCK-SAP (Cat. #IT-31) This new targeted toxin is a chemical conjugate of sulfonated cholecystokinin (CCK) and the ribosome-inactivating protein, saporin. CCK is widely distributed in the central nervous system and the gastrointestinal tract. CCK-SAP is an effective tool to study eating disorders and pain transmission. CCK-SAP eliminates cells recognizing sulfonated CCK. All other cells are

NPY-SAP (Cat. #IT-28) NPY-SAP is a chemical conjugate of neuropeptide Y (NPY) and the ribosome-inactivating protein, saporin. NPY is the most abundant neuropeptide in the brain and is involved in many processes from prenatal to mature animals. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities,

Anti-M-ZAP (Cat. #IT-30) Anti-M-ZAP is another product in the line of second immunotoxins. Second immunotoxins are conjugations of a secondary antibody to the ribosome-inactivating protein, saporin. The second immunotoxin uses the secondary antibody to “piggyback” onto YOUR primary antibody in order to evaluate the ability of the primary antibody to internalize. Anti-M-ZAP is a chemical

It’s routine for primary neuronal cultures to have “contamination” with naturally occurring microglia. But what happens when you don’t want these little creatures or the cytokines and cytotoxins that they release? Or you want to eliminate any effect that microglia have on neurons or astrocytes? ATS has the cheap, effective and very simple solution for

Advanced Targeting Systems announces its new fluorescent second antibody, FITC-labeled goat anti-rabbit IgG (Cat. #FL-04). This fluorescent conjugate is made with all the care that you expect from ATS. The figure above shows its use in flow cytometry on cells that express p75 and your results from immunohistochemistry should be just as clean. Look for

We have re-designed the anti-murine p75-Saporin targeted toxin (mu p75-SAP, Cat. #IT-16) and have produced a conjugate that is much more potent in our in vitro cell cytotoxicity assays. Previously, we used a rat monoclonal antibody. This antibody had been outperformed by our rabbit polyclonal AB-N01, in several assays, especially FACS analysis of murine p75-expressing

Advanced Targeting Systems has introduced important new toxins for investigation into cells that express the interleukin-2 (IL-2) receptor and especially the workings of the immune system. Anti-CD25-saporin (Anti-Tac-SAP) conjugates are directed to the human IL-2 receptor or to the mouse IL-2 receptor. This marker for activated T lymphocytes allows removal of this important group of

Advanced Targeting Systems is pleased to announce the availability of polyclonal antibodies to somatostatin receptor (SSTr) sub-types 1 and 4. SSTr1 antiserum, Cat. #AB-N19 SSTr1 affinity-purified, Cat. #AB-N20AP SSTr4 affinity-purified, Cat. #AB-N21AP Antibody to SSTr1 SSTr1 is a 391 amino acid G-protein-coupled receptor that contains three glycosylation sites and that is expressed in several areas