Targeting Topics

Exposure to Low Environmental Concentrations of Manganese, Lead, and Cadmium Alters the Serotonin System of Blue Mussels. Fraser M, Fortier M, Foucher D, Roumier PH, Brousseau P, Fournier M, Surette C, & Vaillancourt C. (2017). Environmental Toxicology and Chemistry, 37 (1):192-200. Objective: To determine the effects of exposure to Mn, Pb, or Cd on serotonin levels, monoamine oxidase […]

Targeting of Embryonic Annexin A2 Expressed on Ovarian and Breast Cancer by the Novel Monoclonal Antibody 2448. (2018) Cua S, Tan HL, Fong WJ, Chin A, Lau A, Ding V, Song Z, Yang Y, & Choo A. Oncotarget, 9 (17):13206-13221. [PMID 29568351] Objective: To develop mAbs to potentially target oncofetal antigens and be repurposed for antibody

SSP-SAP [Stable analog of Substance P conjugated to Saporin] (Cat. #IT-11) Objective:  To determine the the mechanisms mediating the induction of opioid-induced hyperalgesia and the prolongation of prostaglandinE2-induced hyperalgesia in type II hyperalgesic priming. Summary:  The authors show that understanding the mechanisms responsible for the induction of type II hyperalgesic priming, a form of neuroplasticity in the

Anti-DBH-SAP, Cat. #IT-03[Dopamine Beta Hydroxylase antibody conjugated to Saporin] Objective: To investigate the role of hindbrain catecholamine neuron pathways and their contribution to long-term energy homeostasis by controlling obesogenic sensitivity to a high-fat, high sucrose choice diet. Summary: The authors show that catecholamine neurons (primarily in the VLM and NTS) convey essential feedback signals to

Streptavidin-ZAP[Streptavidin conjugated to Saporin](Cat. #IT-27) Objective: To determine if an immunotoxin cocktail targeted to multiple epitopes has synergistic effects on low expression level cells, which would expand the applicable range of immunotoxin therapy for cancer. Summary: The combination of immunotoxins with different mechanisms of action in an antibody cocktail will increase cytotoxic activities and decrease

NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP) Objective: To determine if differentiated neural crest cells are promising supporting cell candidates to aid in peripheral nerve repair. Summary: In this study, neural crest cells were differentiated from human embryonic stem cells. NGFR (mouse monoclonal, 1:100) Immunocytochemistry.  The specificity of NGFR antibody was validated by immunocytochemical

Congratulations to the Selbo laboratory for their recent publication using Anti-CD105-SAP. This targeted toxin was previously part of the BETA program. As first to publish using this product, Selbo’s group receives a $500 product credit and applause for their great work. 5-Fu Resistant Emt-Like Pancreatic Cancer Cells Are Hypersensitive to Photochemical Internalization of the Novel

Aptamers are small, synthetic, single-stranded nucleic acids that fold into unique secondary structures. Unlike peptides and monoclonal antibodies, they are essentially non-immunogenic even when administered in excess amounts. The publications below explain how biotinylated aptamers combined with Streptavidin-conjugated saporin (Streptavidin-ZAP) can be used to screen aptamers for their ability to internalize into a specific cell

Characterization of the First Fully Human Anti-Tem1 Scfv in Models of Solid Tumor Imaging and Immunotoxin-Based Therapy. Yuan, X, Yang, M, Chen, X, et al. (2018). Cancer Immunol Immunother 2018/01/10. Streptavidin-ZAP (Cat. #IT-27) Objective: ScFv78 was conjugated with the ribosome-inactivating protein saporin (Streptavidin-ZAP) to evaluate whether scFv78 may be used as a vehicle for theTEM1-targeted

2018 starts off with 3 new publications using ATS products. Check out these articles and take advantage of special promotions for each of the products used. Melanopsin Retinal Ganglion Cells Are Not Labeled in Thy-1yfp-16 Transgenic Mice. Grillo, SL, & Stella, SL, Jr. (2018). Neuroreport, 29 (2):118-122. 2017/12/19. Objective: to determine whether mRGCs are labeled