Advanced Targeting Systems announces a new reagent for the study of the serotonergic systems—a monoclonal antibody to the serotonin transporter (Cat. #AB-N09). This murine monoclonal is made with a peptide from an extracellular domain of rat serotonin re-uptake transporter (SERT), and thus is able to attach to cells that express SERT. Homology with the human […]
Targeting Tools: Serotonin Transporter Antibody Read More »
Dr. Douglas Lappi, Chief Scientific Officer, Advanced Targeting Systems The field of targeted toxins has made enormous strides in the years since Advanced Targeting Systems introduced the first research targeted toxin in 1994. We now offer 16 different targeted toxins, with more on the way. The number of important papers in high impact journals continues
Cover Article: Control Conjugates – The Perfect Companion for Targeted Toxins Read More »
Read the 2001 Newsletters and recent scientific references 2001, issue 1: Immunolesioning: From Spinal Cord to Brain / by Schreihofer A / featuring Anti-DBH-SAP (Cat. #IT-03) Jennifer Martin wins “ATS Abstract of the Year Award” Targeting Talk: In vivo Use of Targeted Toxins Targeting Tools: IB4-SAP 2001, issue 2: Safety Studies Begin for Chronic Pain Therapeutic Targeting
Targeting Trends 2001 Newsletter Read More »
Work on hypocretin, or orexin, as it is also known, is some of the most interesting in all of biology these days. When first characterized a mere three years ago by two groups, it was thought to be involved in feeding (hence the name orexin from the Greek orexis meaning appetite). But two articles exploded
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On Saturday, September 22, I attended the Tony Mezzadri Surf Contest in Ocean Beach, California. A number of years ago Tony, surfing at the Ocean Beach pier, was paralyzed with no movement in his legs and limited movement in his hands and arms. The Ocean Beach community rose to help Tony and this contest has been
Targeting Article: Surfing to Help Spinal Cord Injuries Read More »
In September, Advanced Targeting Systems received two Small Business Innovation Research (SBIR) awards from the National Institutes of Health. The first is a Phase II grant from the National Institute of Neurological Disorders and Stroke. This project continues a collaboration with Drs. Joanne Berger-Sweeney (Wellesley College) and Mark Baxter (Harvard University) to further develop the
Targeting Article: ATS Receives $900,000 in NIH Funding Read More »
Dr. Robert Sloviter, University of Arizona, contributes this issue’s article from the laboratories of ATS customers. Dr. Sloviter summarizes his research with SSP-saporin, which he and his graduate student Jennifer Martin used to examine the role of inhibitory neurons in maintaining normal network excitability. The mammalian hippocampus is perhaps the most intensely studied brain region
Cover Article: Immunolesioning Hippocampal Inhibitory Interneurons Read More »
Saporin is a 30 kDa protein isolated from the seeds of the plant Saponaria officinalis. This pleasant resident of the banks of Southern European streams has long been known for medicinal properties, mainly due to its saponins, detergents that reside especially in the roots of the plant and which give the plant its name. It
Targeting Tools: Saporin – a ribosome-inactivating protein Read More »
Advanced Targeting Systems announces the release of its new, very exciting targeted toxin, dermorphin-SAP. It is a conjugate of the mu opioid receptor (MOR) agonist dermorphin and the ribosome-inactivating protein, saporin. Its cytotoxicity to cells that express the MOR promise to make it an important tool in the discovery and definition of the role of
Cover Article: Dermorphin-SAP Kills MOR-Positive Cells Read More »
Advanced Targeting Systems announces two new control molecules for use with immunotoxins. We now offer mouse IgG (Cat. #IT-18) or rat IgG (Cat. #IT-17) conjugated to saporin. These new controls are the same molecular weight, consist of similar, comparable materials — saporin and a rat or mouse IgG — and are synthesized with the same
Targeting Tools: Controls for Immunotoxins Read More »