Targeting Topics

Fab-pHast products bind to your primary antibody via a secondary antibody or Streptavidin cross-linked to a pH-dependent fluorescent reporter.  This fluorescent reporter increases intensity as the pH of its surroundings becomes more acidic, as evident when exposed to the environment inside a cell. SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked

Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-Yloxy)Phenyl]-2-(Morpholin-4-Yl)Acetamide Dihydrochloride (Suvn-G3031): A Novel, Potent, Selective, and Orally Active Histamine H3 Receptor Inverse Agonist with Robust Wake-Promoting Activity. (2019). J Med Chem, 62 (3):1203-1217. Nirogi R, Shinde A, Mohammed AR, Badange RK, Reballi V, Bandyala TR, Saraf SK, Bojja K, Manchineella S, Achanta PK, Kandukuri KK, Subramanian R, Benade V,

Leptin receptor-expressing neurons in the ventromedial nucleus of the hypothalamus contribute to weight loss caused by fourth ventricle leptin infusions. (2019). Am J Physiol Endocrinol Metab  PMID: 31361549Seamon M, Ahn W, Li A-J, Ritter S, & Harris RBS. IT-47:  Leptin-SAP Objective: To test the importance of VMH leptin responsiveness in mediating weight loss caused by fourth ventricle

Neuroprotective Effects of Exercise on the Morphology of Somatic Motoneurons Following the Death of Neighboring Motoneurons. (2019). Chew C, & Sengelaub DR. Neurorehabil Neural Repair, epub ahead of print 1545968319860485.  IT-14:  CTB-SAP Objective:  To explore whether exercise shows the same neuroprotective effect on induced dendritic atrophy as that seen with androgen treatment.Summary:  Exercise following neural

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. (2019). Cell Reports, 28 (3):625-639.e626. Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, Eva C, & Goulding M. Objective:  To determine the central pathway for mechanical itch.Summary:  NPY-Y1 signaling regulates the transmission of innocuous tactile information by establishing biologically relevant thresholds for

3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain. Nizari S, Carare RO, Romero IA, & Hawkes CA. (2019). Front Aging Neurosci, 11 (172).  IT-16: mu p75-SAP Objective:  To further characterize the effect of the loss of cholinergic innervation on the NVU

Latest research using 192-IgG-SAP to eliminate p75-positive neurons. Nitric Oxide Donor Molsidomine Promotes Retrieval of Object Recognition Memory in a Model of Cognitive Deficit Induced by 192 IgG-Saporin. (2019). Behav Brain Res, 366 108-117. Hernández-Melesio MA, Alcaraz-Zubeldia M, Jiménez-Capdeville ME, Martínez-Lazcano JC, Santoyo-Pérez ME, Quevedo-Corona L, Gerónimo-Olvera C, Sánchez-Mendoza A, Ríos C, & Pérez-Severiano F.

Stem cell research has great potential to understand, treat and cure diseases.  By watching stem cells mature into cells in bones, heart muscle, nerves, and other organs and tissue, researchers can determine how diseases and conditions develop.  Here are some recent publications that use ATS products to advance research involving stem cells. Figure Legend.  Non-genotoxic conditioning for hematopoietic stem cell transplantation

Glioblastoma, or glioblastoma multiforme (GBM), is a rare disease, with a global incidence of <10 per 100,000 people; the prognosis is very poor.  Here are a couple of recent studies testing targeted saporin therapies. Integrin α10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival. Munksgaard Thorén M, Chmielarska Masoumi K, Krona C,