Author name: Kristen Hartman

Chemical strategies for antigen-selective targeting of autoreactive B Cells. Chapter 2: Sequential prodrug strategy to target and eliminate ACPA-selective autoreactive B cells.

Lelieveldt L (2019) Chemical strategies for antigen-selective targeting of autoreactive B Cells. Chapter 2: Sequential prodrug strategy to target and eliminate ACPA-selective autoreactive B cells. Radboud Universiteit Nijmegen Nijmegen, Netherlands 45-64. Thesis. Objective: To develop a method to target and selectively eliminate autoreactive B cells that produce anti-citrullinated proteins antibodies (ACPA) using a sequential antigen […]

Chemical strategies for antigen-selective targeting of autoreactive B Cells. Chapter 2: Sequential prodrug strategy to target and eliminate ACPA-selective autoreactive B cells. Read More »

Targeted hippocampal GABA neuron ablation by stable substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats.

Chun E, Bumanglag AV, Burke SN, Sloviter RS (2019) Targeted hippocampal GABA neuron ablation by stable substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats. Epilepsia 60(5):e52-e57. doi: 10.1111/epi.14723 Objective: Hippocampal GABA neurons were targeted for selective elimination to determine whether a focal hippocampal GABAergic defect in an otherwise normal brain can initiate cryptogenic

Targeted hippocampal GABA neuron ablation by stable substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats. Read More »

Spinal somatostatin-positive interneurons transmit chemical itch.

Fatima M, Ren X, Pan H, Slade HFE, Asmar AJ, Xiong CM, Shi A, Xiong AE, Wang L, Duan B (2019) Spinal somatostatin-positive interneurons transmit chemical itch. Pain 160(5):1166-1174. doi: 10.1097/j.pain.0000000000001499 Objective: To further study the cellular identity of spinal interneurons that contribute to itch processing. Summary: Findings reveal a novel spinal mechanism for sensory

Spinal somatostatin-positive interneurons transmit chemical itch. Read More »

Viability of mouse retinal explant cultures assessed by preservation of functionality and morphology

Alarautalahti V, Ragauskas S, Hakkarainen JJ, Uusitalo-Järvinen H, Uusitalo H, Hyttinen J, Kalesnykas G, Nymark S (2019) Viability of mouse retinal explant cultures assessed by preservation of functionality and morphology. Invest Ophthalmol Vis Sci 60(6):1914-1927. doi: 10.1167/iovs.18-25156 PMID: 31042799 Summary: Organotypic retinal explant cultures have been used to study retinal development, retinal diseases and injuries,

Viability of mouse retinal explant cultures assessed by preservation of functionality and morphology Read More »

Cell-specific ablation of GnRH neurons using kisspeptin-saporin in the preoptic area of sheep, but not mice.

Porter D, Moore A, Goodman R, Hileman S, Coolen L, Lehman M (2019) Cell-specific ablation of GnRH neurons using kisspeptin-saporin in the preoptic area of sheep, but not mice. J Endocrine Society 3(1):SAT–421. ENDO 2019 – 101st Annual Meeting of the Endocrine Society, New Orleans, Louisiana doi: 10.1210/js.2019-SAT-421 Objective: To invesigate the potential of integrin

Cell-specific ablation of GnRH neurons using kisspeptin-saporin in the preoptic area of sheep, but not mice. Read More »

Losartan, an angiotensin II type 1 receptor antagonist, alleviates mechanical hyperalgesia in a rat model of chemotherapy-induced neuropathic pain by inhibiting inflammatory cytokines in the dorsal root ganglia.

Kim E, Hwang S-H, Kim H-K, Abdi S, Kim HK (2019) Losartan, an angiotensin II type 1 receptor antagonist, alleviates mechanical hyperalgesia in a rat model of chemotherapy-induced neuropathic pain by inhibiting inflammatory cytokines in the dorsal root ganglia. Mol Neurobiol 56(11):7408-7419. doi: 10.1007/s12035-019-1616-0 PMID: 31037647 Objective: To assess losartan’s analgesic effect on paclitaxel-induced neuropathic

Losartan, an angiotensin II type 1 receptor antagonist, alleviates mechanical hyperalgesia in a rat model of chemotherapy-induced neuropathic pain by inhibiting inflammatory cytokines in the dorsal root ganglia. Read More »

Integrin α10, a novel therapeutic target in glioblastoma, regulates cell migration, proliferation, and survival.

Thorén MM, Chmielarska Masoumi K, Krona C, Huang X, Kundu S, Schmidt L, Forsberg-Nilsson K, Floyd Keep M, Englund E, Nelander S, Holmqvist B, Lundgren-Åkerlund E (2019) Integrin α10, a novel therapeutic target in glioblastoma, regulates cell migration, proliferation, and survival. Cancers (Basel) 11(4):587. doi: 10.3390/cancers11040587 PMID: 31027305 Objective: To investigate the potential of integrin

Integrin α10, a novel therapeutic target in glioblastoma, regulates cell migration, proliferation, and survival. Read More »

Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways.

Pang HW, Linares A, Couling L, Santollo J, Ancheta L, Daniels D, Speth RC (2019) Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways. Endocrine 66(2):349-359. doi: 10.1007/s12020-019-01930-z Objective: To study the ability of a novel bovine serum albumin-angiotensin II (BSA-Ang II) conjugate to effect responses of the AT1 angiotensin II receptor

Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways. Read More »

Regulation of memory function by feeding-relevant biological systems: Following the breadcrumbs to the hippocampus

Suarez AN, Noble EE, Kanoski SE (2019) Regulation of memory function by feeding-relevant biological systems: Following the breadcrumbs to the hippocampus. Front Mol Neurosci 12:101. doi: 10.3389/fnmol.2019.00101 PMID: 31057368 Objective: To review the literature describing interconnections between the memory and feeding circuits of the body. Summary: Gastrointestinal and memory systems within the body are heavily

Regulation of memory function by feeding-relevant biological systems: Following the breadcrumbs to the hippocampus Read More »

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