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Spinal somatostatin-positive interneurons transmit chemical itch.

Fatima M, Ren X, Pan H, Slade HFE, Asmar AJ, Xiong CM, Shi A, Xiong AE, Wang L, Duan B (2019) Spinal somatostatin-positive interneurons transmit chemical itch. Pain 160(5):1166-1174. doi: 10.1097/j.pain.0000000000001499

Objective: To further study the cellular identity of spinal interneurons that contribute to itch processing.

Summary: Findings reveal a novel spinal mechanism for sensory encoding of itch perception.

Usage: Npra receptor–expressing spinal cord interneurons were ablated through intrathecal injection of Nppb-SAP (5 μg/10 μL) or control Blank-SAP in lumbar segment 3 to 4. Behavioral analyses were performed 1 week after the toxin injection.

Related Products: Nppb-SAP (Cat. #IT-69), Blank-SAP (Cat. #IT-21)

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