Author name: Kristen Hartman

Novel approaches towards cancer-directed immune checkpoint inhibition

Ploeg E (2023) Novel approaches towards cancer-directed immune checkpoint inhibition. Univ Groningen Thesis. doi: 10.33612/diss.737906343 Objective: To evaluate a novel bispecific antibody, bsAb CD73xEGFR, that inhibits the immunosuppressive enzyme CD73 on cancer cells in an EGFR-directed manner. Summary: The researchers constructed a bispecific antibody, bsAb CD73xEGFR, that binds to both CD73 and EGFR on cancer […]

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Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases

Jin X, Yang GY (2023) Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases. Prog Lipid Res 101241. doi: 10.1016/j.plipres.2023.101241 PMID: 37524133 Objective: The authors review the tumor-related biological functions of GSLs and recent progress in using GSLs and related enzymes to diagnose and treat tumor diseases. Summary: Glycosphingolipids (GSLs)

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Mobilization-based engraftment of haematopoietic stem cells: a new perspective for chemotherapy-free gene therapy and transplantation

Canarutto D, Omer Javed A, Pedrazzani G, Ferrari S, Naldini L (2023) Mobilization-based engraftment of haematopoietic stem cells: a new perspective for chemotherapy-free gene therapy and transplantation. Br Med Bull ldad017. doi: 10.1093/bmb/ldad017 PMID: 37460391 Objective: The authors review alternative chemotherapy-free approaches to niche voidance that could replace conventional regimens and alleviate the morbidity of

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Elimination of NPYR+ Neurons with NPY-Saporin : A Review of the Literature

Targeting Topics /

Elimination of NPYR+ Neurons with NPY-Saporin : A Review of the Literature Patrick A. Shramm, Denise Higgins, Douglas A. Lappi • Advanced Targeting Systems, Carlsbad, CA Abstract Introduction: NPY-SAP is a conjugate of Neuropeptide Y and the ribosome-inactivating protein (RIP) saporin. The idea behind the invention of NPY-SAP is to introduce it using the ligand’s

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The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression

Kfoury YS, Ji F, Jain E, Mazzola MC, Schiroli G, Papazian A, Mercier FE, Sykes DB, Kiem A, Randolph MA, Abdel-Wahab OI, Calvi LM, Sadreyev R, Scadden DT (2023) The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression. Blood Adv bloodadvances.2022008268. doi: 10.1182/bloodadvances.2022008268 PMID: 37450380 Objective: Evaluate mesenchymal cell molecular

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Cell-Penetrating Peptide-Based Delivery of Macromolecular Drugs: Development, Strategies, and Progress

Sun Z, Huang J, Fishelson Z, Wang C, Zhang S (2023) Cell-Penetrating Peptide-Based Delivery of Macromolecular Drugs: Development, Strategies, and Progress. Biomedicines 11(7):1971. doi: 10.3390/biomedicines11071971 PMID: 37509610 Objective: Review the development process of cell penetrating peptides and summarize the composition and classification of the penetrating peptide-based delivery systems, cellular uptake mechanisms, influencing factors, and biological

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Custom Biotinylation Service Overview

Video /

Also available in Chinese | French | German | Italian | Japanese | Korean | Portuguese | Spanish Leonardo Ancheta, Vice President and Director of Custom Conjugations at ATS, talks about important things to watch for to avoid compromising your next experiment. keywords: biotinylation service, custom, streptavidin-ZAP, streptavidinylated saporin, biotin, linker, target-binding affinity, stable, payload,

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Dynamically crosslinked nanocapsules for the efficient and serum-resistant cytosolic protein delivery

Yang Q, Liu N, Zhao Z, Liu X, Yin L (2024) Dynamically crosslinked nanocapsules for the efficient and serum-resistant cytosolic protein delivery. Nano Research 17:1760-1771. doi: 10.1007/s12274-023-5978-2 Objective: Improve protein delivery with the synthesis of epigallocatechin gallate/low-molecular-weight polyethylenimine/2-acetylphenylboric acid (EPP)-protein nano-capsules. Summary: A protein delivery strategy was created through the crosslinking of various markers on

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