Author name: Kristen Hartman

Lesions of kndy and kiss1r neurons in the arcuate nucleus produce different effects on lh pulse patterns in female sheep

Goodman RL, Moore AM, Onslow K, Hileman SM, Hardy SL, Bowdridge EC, Walters BA, Agus S, Griesgraber MJ, Aerts EG, Lehman MN, Coolen LM (2023) Lesions of kndy and kiss1r neurons in the arcuate nucleus produce different effects on lh pulse patterns in female sheep. Endocrinology 164(11):bqad148. doi: 10.1210/endocr/bqad148 PMID: 37776515 Objective: To test the […]

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Regulation of nociception threshold by norepinephrine through adrenergic α2 receptor in rat models of Parkinson’s disease

Gao Q, Zhang Y, Wang X, Wang R, Zhang L (2024) Regulation of nociception threshold by norepinephrine through adrenergic α2 receptor in rat models of Parkinson’s disease. CNS Neurosci Ther 30(3):e14446. doi: 10.1111/cns.14446 PMID: 37721421 Objective: To investigate the effect of norepinephrine on the activation of brain cells through adrenergic α2 receptor, to regulate the

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Exploring the potential of nanogels: From drug carriers to radiopharmaceutical agents

Kubeil M, Suzuki Y, Casulli MA, Kamal R, Hashimoto T, Bachmann M, Hayashita T, Stephan H (2023) Exploring the potential of nanogels: From drug carriers to radiopharmaceutical agents. Adv Healthc Mater e2301404. doi: 10.1002/adhm.202301404 PMID: 37717209 Summary: This review provides a brief overview of current developments of nanogels in the fields of drug delivery, therapeutic

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Validated Antibodies: NGFR & Melanopsin

Validated Antibodies targeting NGFR and Melanopsin NGFR Antibodies NGFR (mu p75) Rabbit Polyclonal [AB-N01] AB-N01 also known as mu p75, and the affinity-purified version, AB-N01AP recognize the p75 receptor in mouse. Applications include immunohistochemistry, immunoprecipitation, immunoblotting, flow cytometry, and blocking the function of nerve growth factor receptor. NGFR (ME20.4, p75) Mouse Monoclonal [AB-N07] AB-N07 also known

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Nucleolin‑based targeting strategies in cancer treatment: Focus on cancer immunotherapy (Review)

Thongchot S, Aksonnam K, Thuwajit P, Yenchitsomanus PT, Thuwajit C (2023) Nucleolin‑based targeting strategies in cancer treatment: Focus on cancer immunotherapy (Review). Int J Mol Med 52(3):81. doi: 10.3892/ijmm.2023.5284 PMID: 37477132 Objective: The authors review the mechanisms through which the multiple functions of NCL can participate in the progression of cancer. In addition, the studies

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pHast Conjugate Videos

pHast Conjugate Videos An introduction to our pHast product line: pH-sensitive fluorescent secondary conjugates designed to fluoresce when exposed to the environment inside of a cell. Also available in Chinese | French | German | Italian | Japanese | Korean | Portuguese | Spanish Also available in Chinese | French | German | Italian |

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Screening targeting agents and their cell surface biomarkers for high specificity and rapid internalization via cell death and fluorescence.

Screening targeting agents and their cell surface biomarkers for high specificity and rapid internalization via cell death and fluorescence. Ancheta L, Bouajram R, Lappi DA (2018) Society for Neuroscience, San Diego, CA. Abstract Some of the most recent successes in the treatment of cancers or research into passive immunotherapies for neurodegenerative diseases, employ the use

Screening targeting agents and their cell surface biomarkers for high specificity and rapid internalization via cell death and fluorescence. Read More »

PTGFRN as a target for antibody-drug conjugate (ADC) development in mesothelioma and medulloblastoma

Marquez J (2023) PTGFRN as a target for antibody-drug conjugate (ADC) development in mesothelioma and medulloblastoma. Univ Maryland Baltimore Thesis. Objective: To investigate the role of Prostaglandin F2 Receptor Negative (PTGFRN) regulator in cancer progression and develop an antibody-drug conjugate (ADC) targeting PTGFRN for the treatment of mesothelioma and pediatric medulloblastoma. Summary: This dissertation explores

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Emerging non-viral vectors for gene delivery

Wang C, Pan C, Yong H, Wang F, Bo T, Zhao Y, Ma B, He W, Li M (2023) Emerging non-viral vectors for gene delivery. J Nanobiotechnology 21(1):272. doi: 10.1186/s12951-023-02044-5 PMID: 37592351 Summary: This review describes the fastest-growing and efficient non-viral gene delivery vectors that include liposomes and lipid nanoparticles (LNPs), highly branched poly(β-amino ester)

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DichroIDP: a method for analyses of intrinsically disordered proteins using circular dichroism spectroscopy

Miles AJ, Drew ED, Wallace BA (2023) DichroIDP: a method for analyses of intrinsically disordered proteins using circular dichroism spectroscopy. Commun Biol 6(1):823. doi: 10.1038/s42003-023-05178-2 PMID: 37553525 Objective: To use DichroIDP software to analyze secondary structures of proteins containing disordered structures via circular dichroism spectroscopy. Summary: Globular proteins have specific shapes and mainly contain standard

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