Author name: Kristen Hartman

Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin

Allred CA, Gormley C, Venugopal I, Li S, McGuire MJ, Brown KC (2023) Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin. Commun Biol 6(1):60. doi: 10.1038/s42003-022-04385-7 PMID: 36650239 Objective: The demonstration of a peptide optimized by chemical modifications for tumor specificity to deliver saporin, a catalytic toxin, specifically to cancer cells via both in […]

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New methods to investigate the GnRH pulse generator

Ivanova D, O’Byrne KT (2024) New methods to investigate the GnRH pulse generator. J Mol Endocrinol 72(2):e230079. doi: 10.1530/JME-23-0079 PMID: 38085702 Objective: To review the latest methodologies and insights into the GnRH pulse generator and its role in regulating reproductive hormone secretion. Summary: The paper discusses recent advancements in understanding the GnRH pulse generator and

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Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice

Maiarù M, Leese C, Silva-Hucha S, Fontana-Giusti S, Tait L, Tamagnini F, Davletov B, Hunt SP (2024) Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice. J Pain 25(6):104466. doi: 10.1016/j.jpain.2024.01.331 PMID: 38218509 Summary: The authors discuss how Substance P-Botulinum is used to

Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice Read More »

Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating

McDougle M, de Araujo A, Singh A, Yang M, Braga I, Paille V, Mendez-Hernandez R, Vergara M, Woodie LN, Gour A, Sharma A, Urs N, Warren B, de Lartigue G (2024) Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating. Cell Metab 36:1-15. doi: 10.1016/j.cmet.2023.12.014 PMID: 38242133 Objective: To investigate the separate

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Preservation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in late adult mice: Implications as a potential biomarker for early onset ocular degenerative diseases

Matynia A, Recio BS, Myers Z, Parikh S, Goit RK, Brecha NC, Pérez de Sevilla Müller L (2024) Preservation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in late adult mice: Implications as a potential biomarker for early onset ocular degenerative diseases. Invest Ophthalmol Vis Sci 65(1):28. doi: 10.1167/iovs.65.1.28 PMID: 38224335 Objective: To assess the preservation

Preservation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in late adult mice: Implications as a potential biomarker for early onset ocular degenerative diseases Read More »

Self-assembly of epitope-tagged proteins and antibodies for delivering biologics to antigen presenting cells

Gong S, Qiu J, Thayumanavan S (2024) Self-assembly of epitope-tagged proteins and antibodies for delivering biologics to antigen presenting cells. J Am Chem Soc 146(1):33-38. doi: 10.1021/jacs.3c09334 PMID: 38147631 Objective: To describe a simple self-assembly strategy for generating artificial immune complexes. Summary: The built-in recognition domains in the antibody, viz. the Fab and Fc domains,

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Heterophyllin: A new adenia toxic lectin with peculiar biological properties

Bortolotti M, Biscotti F, Zanello A, Polito L, Bolognesi A (2024) Heterophyllin: A new adenia toxic lectin with peculiar biological properties. Toxins 16(1):1. doi: 10.3390/toxins16010001 PMID: 38276525 Objective: Describe the novel type II Ribosome Inactivating Protein, Heterophyllin. Summary: Heterophyllin, a novel toxic lectin from Adenia heterophylla shows enzymatic and lectin properties of type 2 RIPs.

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Intracellular protein delivery: Approaches, challenges, and clinical applications

Chan A, Tsourkas A (2024) Intracellular protein delivery: Approaches, challenges, and clinical applications. BME Frontiers 5:0035. doi: 10.34133/bmef.0035 PMID: 38282957 Objective: To review progress made towards achieving cytosolic delivery of recombinant proteins and possible strategies to enable proteins to cross cell membranes. Summary: Drug delivery researchers have worked to deliver saporin into tumor cells in

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Immunomodulatory impact of memory T lymphocyties in periodontitis

de Paula FS (2023) Immunomodulatory impact of memory T lymphocyties in periodontitis. Univ Minnesota Thesis. Objective: This thesis paper sought to determine whether local reactivation of oral tissue resident memory cells (TRM) of a defined antigen specificity could exacerbate ligature-induced periodontal (LIP), a model for periodontal disease in mice. Summary: Reactivation of oral TRM aggravated

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