Author name: Kristen Hartman

The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats.

Maejima Y, Yokota S, Horita S, Shimomura K (2019) The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats. Sci Rep 9(1):11848. doi: 10.1038/s41598-019-48336-5 Objective: To determine the underlying mechanisms that induce high energy intake (EI) per body weight (BW). Summary: Undeveloped properties of VTA GABA […]

The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats. Read More »

Orexin-SAP Model of Sleep Disorders

Targeting Topics /

Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-Yloxy)Phenyl]-2-(Morpholin-4-Yl)Acetamide Dihydrochloride (Suvn-G3031): A Novel, Potent, Selective, and Orally Active Histamine H3 Receptor Inverse Agonist with Robust Wake-Promoting Activity. (2019). J Med Chem, 62 (3):1203-1217. Nirogi R, Shinde A, Mohammed AR, Badange RK, Reballi V, Bandyala TR, Saraf SK, Bojja K, Manchineella S, Achanta PK, Kandukuri KK, Subramanian R, Benade V,

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Selective role of neurokinin B in IL-31–induced itch response in mice.

Sakata D, Uruno T, Matsubara K, Andoh T, Yamamura K, Magoshi Y, Kunimura K, Kamikaseda Y, Furue M, Fukui Y (2019) Selective role of neurokinin B in IL-31–induced itch response in mice. J Allergy Clin Immunol 144(4):1130-1133. doi: 10.1016/j.jaci.2019.06.031 Objective: To examine the physiological significance of neurokinin B in IL-31–induced itch sensation. Summary: IL-31–induced scratching

Selective role of neurokinin B in IL-31–induced itch response in mice. Read More »

Leptin responsiveness in mediating weight loss

Targeting Topics /

Leptin receptor-expressing neurons in the ventromedial nucleus of the hypothalamus contribute to weight loss caused by fourth ventricle leptin infusions. (2019). Am J Physiol Endocrinol Metab  PMID: 31361549Seamon M, Ahn W, Li A-J, Ritter S, & Harris RBS. IT-47:  Leptin-SAP Objective: To test the importance of VMH leptin responsiveness in mediating weight loss caused by fourth ventricle

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Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury.

Marvizon JC, Chen W, Fu W, Taylor BK (2019) Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury. Neuropharmacology 158:107732. doi: 10.1016/j.neuropharm.2019.107732 Summary: NPY is released from dorsal horn interneurons or primary afferent terminals by electrical stimulation and by activation of TRPV1, PKA or NMDA receptors

Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury. Read More »

Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.

Małecki JM, Willemen HLDM, Pinto R, Ho AYY, Moen A, Eijkelkamp N, Falnes PØ (2019) Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration. J Biol Chem 294(31):11654-11664. doi: 10.1074/jbc.RA119.009045 PMID: 31213526 Usage: Western blot Related Products: Tri-methyl Lysine Rabbit Polyclonal (Cat. #AB-265)

Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration. Read More »

Mixed vehicle emissions induces angiotensin ii and cerebral microvascular angiotensin receptor expression in C57Bl/6 mice and promotes alterations in integrity in a blood-brain barrier coculture model.

Suwannasual U, Lucero J, Davis G, McDonald JD, Lund AK (2019) Mixed vehicle emissions induces angiotensin ii and cerebral microvascular angiotensin receptor expression in C57Bl/6 mice and promotes alterations in integrity in a blood-brain barrier coculture model. Toxicol Sci 170(2):525-535. doi: 10.1093/toxsci/kfz121 PMID: 31132127 Objective: To investigate the hypothesis that inhalation exposure to a mixture

Mixed vehicle emissions induces angiotensin ii and cerebral microvascular angiotensin receptor expression in C57Bl/6 mice and promotes alterations in integrity in a blood-brain barrier coculture model. Read More »

The role of the brain in the regulation of peripheral noradrenaline-producing organs in rats during morphogenesis.

Murtazina AR, Nikishina YO, Dil’mukhametova LK, Sapronova AY, Ugrumov MV (2019) The role of the brain in the regulation of peripheral noradrenaline-producing organs in rats during morphogenesis. Dokl Biochem Biophys 486(1):243-246. doi: 10.1134/S1607672919030207 Related Products: Anti-DBH-SAP (Cat. #IT-03)

The role of the brain in the regulation of peripheral noradrenaline-producing organs in rats during morphogenesis. Read More »

RGS14414 treatment induces memory enhancement and rescues episodic memory deficits.

Masmudi‐Martin M, Navarro‐Lobato I, López‐Aranda MF, Delgado G, Martín‐Montañez E, Quiros‐Ortega ME, Carretero‐Rey M, Narváez L, Garcia‐Garrido MF, Posadas S, López‐Téllez JF, Blanco E, Jiménez‐Recuerda I, Granados‐Durán P, Paez‐Rueda J, López JC and Khan ZU (2019) RGS14414 treatment induces memory enhancement and rescues episodic memory deficits. FASEB J 33:11804-11820. doi: 10.1096/fj.201900429RR Objective: To investigate the

RGS14414 treatment induces memory enhancement and rescues episodic memory deficits. Read More »

Neuroprotective Effects of Exercise

Targeting Topics /

Neuroprotective Effects of Exercise on the Morphology of Somatic Motoneurons Following the Death of Neighboring Motoneurons. (2019). Chew C, & Sengelaub DR. Neurorehabil Neural Repair, epub ahead of print 1545968319860485.  IT-14:  CTB-SAP Objective:  To explore whether exercise shows the same neuroprotective effect on induced dendritic atrophy as that seen with androgen treatment.Summary:  Exercise following neural

Neuroprotective Effects of Exercise Read More »

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