Author name: Kristen Hartman

Mouse lung organoid responses to reduced, increased, and cyclic stretch

Joshi R, Batie MR, Fan Q, Varisco BM (2022) Mouse lung organoid responses to reduced, increased, and cyclic stretch. Am J Physiol Lung Cell Mol Physiol 322(1):L162-L173. doi: 10.1152/ajplung.00310.2020 PMID: 34851724 Objective: To test two mouse lung organoid mechanotransductive models to address deficiencies in cell culture models. Summary: Cyclic stretch increased TGF-β and integrin-mediated signaling, […]

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Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study

Sanna F, Bratzu J, Angioni L, Pina Sorighe M, Cocco C, Argiolas A, Melis MR (2021) Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study. Brain Res 1773:147705. doi: 10.1016/j.brainres.2021.147705 PMID: 34744015 Objective: To investigate the effects of Oxytocin-SAP in the

Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study Read More »

Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation

Persaud SP, Ritchey JK, Kim S, Lim S, Ruminski PG, Cooper ML, Rettig MP, Choi J, DiPersio JF (2021) Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation. J Clin Invest 131(24):e145501. doi: 10.1172/JCI145501 Objective: To demonstrate that biotinylated anti-CD45-SAP or anti-cKit-SAP mixed with Streptavidin-Saporin along with Janus kinase 1/2, enables

Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation Read More »

The role of BDNF-mediated neuroplasticity in cardiovascular regulation within the hypothalamus and brainstem

Thorsdottir DJ (2021) The role of BDNF-mediated neuroplasticity in cardiovascular regulation within the hypothalamus and brainstem. Univ Vermont, Dept Pharmacology 1387Thesis. Summary: This PhD dissertation to determine the mechanism behind BDNF-mediated cardiovascular regulation. Usage: Rats received bilateral NTS injections of vehicle or Anti-DBH-SAP, which selectively lesions catecholaminergic neurons. Treatment increased blood pressure in the GFP

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Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice

Li Y, Hollis E (2021) Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice. J Neurosci 41(49):10148-10160. doi: 10.1523/JNEUROSCI.1152-21.2021 PMID: 34750228 Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP), mu p75-SAP (Cat. #IT-16)

Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice Read More »

Converting extracellular vesicles into nanomedicine: loading and unloading of cargo

Joshi BS, Ortiz D, Zuhorn IS (2021) Converting extracellular vesicles into nanomedicine: loading and unloading of cargo. Materials Today Nano 16:100148. doi: 10.1016/j.mtnano.2021.100148 Objective: To provide a comprehensive overview of (i) methods for the loading of EVs with therapeutic cargo, (ii) methods for EV surface functionalization to direct EVs to target cells, and (iii) methods

Converting extracellular vesicles into nanomedicine: loading and unloading of cargo Read More »

Perspective: Estrogen and the risk of cognitive decline: a missing choline(rgic) link?

Bortz J, Klatt KC, Wallace TC (2021) Perspective: Estrogen and the risk of cognitive decline: a missing choline(rgic) link?. Adv Nutr 13(2):376-387. doi: 10.1093/advances/nmab145 Objective: Explore the relationship between cognitive aging and sex hormones, the cholinergic system, and choline as an essential nutrient. Summary: This perspective identifies numerous areas for future preclinical and clinical research,

Perspective: Estrogen and the risk of cognitive decline: a missing choline(rgic) link? Read More »

The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development

Kunimura K, Fukui Y (2021) The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development. Int Immunol 33(12):731-736. doi: 10.1093/intimm/dxab065 Objective: To investigate the molecular mechanisms of how IL-31 is produced in helper T cells upon stimulation and transmits the itch sensation to the brain. Summary: This review highlights recent

The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development Read More »

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation.

Wu B, Zhao TV, Jin K, Hu Z, Abdel MP, Warrington KJ, Goronzy JJ, Weyand CM (2021) Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Nat Immunol 22(12):1551-1562. doi: 10.1038/s41590-021-01065-2 Objective: To identify a deficiency of mitochondrial aspartate production as a key abnormality in autoimmune T cells. Summary: Shortage of mitochondrial aspartate disrupted the

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Read More »

Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1-induced satiation

Vana V, Laerke MK, Rehfeld JF, Arnold M, Dmytriyeva O, Langhans W, Schwartz TW, Hansen HS (2022) Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1-induced satiation. Diabetes Obes Metab 24(2):268-280. doi: 10.1111/dom.14575 Objective: To investigate the effect of peripheral GLP-1 on food-intake control. Summary: Endogenous CCK interacts with GLP-1 to promote satiation and

Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1-induced satiation Read More »

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