Author name: Kristen Hartman

Neurodegeneration in the centrally-projecting Edinger-Westphal nucleus contributes to the non-motor symptoms of Parkinson’s disease in the rat

Ujvári B, Pytel B, Márton Z, Bognár M, Kovács LÁ, Farkas J, Gaszner T, Berta G, Kecskés A, Kormos V, Farkas B, Füredi N, Gaszner B (2022) Neurodegeneration in the centrally-projecting Edinger-Westphal nucleus contributes to the non-motor symptoms of Parkinson’s disease in the rat. J Neuroinflammation 19(1):31. doi: 10.1186/s12974-022-02399-w Objective: To investigate whether neuron loss […]

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ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer

Napoli M, Wu SJ, Gore BL, Abbas HA, Lee K, Checker R, Dhar S, Rajapakshe K, Tan AC, Lee MG, Coarfa C, Flores ER (2022) ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer. Nat Commun 13(1):614. doi: 10.1038/s41467-022-28202-1 PMID: 35105868 Objective: To investigate the underlying mechanistic role regulated by

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Comparison of the effects of corneal and lacrimal gland denervation on the lacrimal functional unit of rats

Barros JFF, Sant’Ana AMS, Dias LC, Murashima AAB, Silva LECMD, Fantucci MZ, Rocha EM (2022) Comparison of the effects of corneal and lacrimal gland denervation on the lacrimal functional unit of rats. Arq Bras Oftalmol 85(1):59-67. doi: 10.5935/0004-2749.20220008 Summary: This study compared the changes in the lacrimal functional unit in the following two models of

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Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections

Hickerson BT, Daniels-Wells TR, Payes C, Clark LE, Candelaria PV, Bailey KW, Sefing EJ, Zink S, Ziegenbein J, Abraham J, Helguera G, Penichet ML, Gowen BB (2022) Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections. Nat Commun 13(1):558. doi: 10.1038/s41467-021-27949-3 PMID: 35091550 Objective: Demonstrate that a fusion protein of the antibody (ch128.1/IgG1)

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Antibody based delivery of toxins and other active molecules for cancer therapy

Polito L (2022) Antibody based delivery of toxins and other active molecules for cancer therapy. Biomedicines 10(2):267. doi: 10.3390/biomedicines10020267 PMID: 35203476 Summary: This introduction to studies collected in a special issue that confirmed the potential of immunotherapy for targeted therapy in different cancer models. In the near future, antibody-based therapeutic approaches could improve the outcomes

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A perspective on the applications of functionalized nanogels: promises and challenges

Pinelli F, Saadati M, Zare EN, Makvandi P, Masi M, Sacchetti A, Rossi F (2023) A perspective on the applications of functionalized nanogels: promises and challenges. International Materials Reviews 68(1):1-25. doi: 10.1080/09506608.2022.2026864 Summary: A perspective on the applications of functionalized nanogels: their features such as large surface area, ability to hold molecules, flexibility in size

A perspective on the applications of functionalized nanogels: promises and challenges Read More »

Cytokines in the Brain and Neuroinflammation: We Didn’t Starve the Fire!

Konsman JP (2022) Cytokines in the Brain and Neuroinflammation: We Didn’t Starve the Fire!. Pharmaceuticals (Basel) 15(2):140. doi: 10.3390/ph15020140 PMID: 35215252 Summary: To test the role of IL-1 receptor brain macrophages, the work of Chaskiel et al. employed IL-1 coupled to the ribosome toxin, saporin, and administered this conjugate into forebrain ventricles to effectively reduce

Cytokines in the Brain and Neuroinflammation: We Didn’t Starve the Fire! Read More »

Female-specific mechanisms of nociplastic pain in murine model

Hankerd K (2021) Female-specific mechanisms of nociplastic pain in murine model. The University of Texas Medical Branch at Galveston, Dept Neuroscience Thesis. Objective: To study nociplastic pain the authors developed a murine model in which postinjury thermal stimulation of injured area triggers the transition to a nociplastic pain state more readily in females. Summary: Postinjury

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Expression pattern of brain-derived neurotrophic factor and its associated receptors: Implications for exogenous neurotrophin application

Schulze J, Staecker H, Wedekind D, Lenarz T, Warnecke A (2022) Expression pattern of brain-derived neurotrophic factor and its associated receptors: Implications for exogenous neurotrophin application. Hear Res 413:108098. doi: 10.1016/j.heares.2020.108098 PMID: 33143996 Objective: To investigate the mechanisms of brain-derived neurotrophic factor (BDNF) in the inner ear, by analyzing the expression of mature BDNF (mBDNF),

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Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections

Borkowski LF, Keilholz AN, Smith CL, Canda KA, Nichols NL (2021) Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections. Exp Neurol 347:113892. doi: 10.1016/j.expneurol.2021.113892 Objective: To determine the effect of ketoprofen delivery on enhanced phrenic long-term facilitation (pLTF) Summary: pLTF was surprisingly

Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections Read More »

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