Author name: Kristen Hartman

Identification of prostaglandin F2 receptor negative regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development

Marquez J, Dong J, Dong C, Tian C, Serrero G (2021) Identification of prostaglandin F2 receptor negative regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development. PLoS One 16(1):e0246197. doi: 10.1371/journal.pone.0246197 Summary: PTGFRN is a cell-surface protein that is upregulated in certain cancer types, including head and neck and, notably, pediatric […]

Identification of prostaglandin F2 receptor negative regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development Read More »

Cholinergic signalling in the forebrain controls microglial phenotype and responses to systemic inflammation

Nazmi A, Griffin EW, Field RH, Doyle S, Hennessy E, O’Donnell M, Rehill A, McCarthy A, Healy D, Doran MM, Lowry JP, Cunningham C (2021) Cholinergic signalling in the forebrain controls microglial phenotype and responses to systemic inflammation. bioRxiv 2021.01.18.427123. doi: 10.1101/2021.01.18.427123 Related Products: mu p75-SAP (Cat. #IT-16)

Cholinergic signalling in the forebrain controls microglial phenotype and responses to systemic inflammation Read More »

Proteome-wide modulation of S-nitrosylation in Trypanosoma cruzi trypomastigotes upon interaction with the host extracellular matrix

Mule SN, Manchola NC, de Oliveira GS, Pereira M, Magalhães RDM, Teixeira AA, Colli W, Alves MJM, Palmisano G (2021) Proteome-wide modulation of S-nitrosylation in Trypanosoma cruzi trypomastigotes upon interaction with the host extracellular matrix. J Proteomics 231:104020. doi: 10.1016/j.jprot.2020.104020 PMID: 33096306 Objective: To map site-specific S-nitrosylated (SNO) proteins from Trypanosoma cruzi trypomastigotes incubated (MTy)

Proteome-wide modulation of S-nitrosylation in Trypanosoma cruzi trypomastigotes upon interaction with the host extracellular matrix Read More »

Disruption of basal forebrain cholinergic neurons after traumatic brain injury does not compromise environmental enrichment-mediated cognitive benefits.

Moschonas EH, Leary JB, Memarzadeh K, Bou-Abboud CE, Folweiler KA, Monaco CM, Bondi CO (2021) Disruption of basal forebrain cholinergic neurons after traumatic brain injury does not compromise environmental enrichment-mediated cognitive benefits. Brain Res 1751:147175. doi: 10.1016/j.brainres.2020.147175 Objective: To determine if basal forebrain cholinergic neurons are important mediators of environmental enrichment (EE)-induced benefits after traumatic

Disruption of basal forebrain cholinergic neurons after traumatic brain injury does not compromise environmental enrichment-mediated cognitive benefits. Read More »

Oxytocin influences male sexual activity via non-synaptic axonal release in the spinal cord.

Oti T, Satoh K, Uta D, Nagafuchi J, Tateishi S, Ueda R, Takanami K, Young LJ, Galione A, Morris JF, Sakamoto T, Sakamoto H (2021) Oxytocin influences male sexual activity via non-synaptic axonal release in the spinal cord. Curr Biol 31(1):103-114.e5. doi: 10.1016/j.cub.2020.09.089 Summary: Oxytocin directly activates SEG (Spinal Ejaculation Generator)/GRP (Gastrin-Releasing Peptide) neurons via

Oxytocin influences male sexual activity via non-synaptic axonal release in the spinal cord. Read More »

Leech extract: A candidate cardioprotective against hypertension-induced cardiac hypertrophy and fibrosis

Wang CH, Pandey S, Sivalingam K, Shibu MA, Kuo WW, Yu-LanYeh, Viswanadha VP, Lin YC, Liao SC, Huang CY (2021) Leech extract: A candidate cardioprotective against hypertension-induced cardiac hypertrophy and fibrosis. J Ethnopharmacol 264:113346. doi: 10.1016/j.jep.2020.113346 PMID: 32896627 Objective: To delineate the molecular mechanisms of medicinal leech extract in the treatment of cardiac hypertrophy and

Leech extract: A candidate cardioprotective against hypertension-induced cardiac hypertrophy and fibrosis Read More »

Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice

Nizari S, Wells JA, Carare RO, Romero IA, Hawkes CA (2021) Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice. Acta Neuropathol Commun 9(1):12. doi: 10.1186/s40478-020-01108-z Summary: In this report, icv administration of mu p75-SAP resulted in significant death of

Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice Read More »

Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder.

Lim I, Mitsui R, Kameda M, Sellers DJ, Chess‐Williams R, Hashitani H (2021) Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder. Neurourol Urodyn 40:102-111. doi: 10.1002/nau.24548 PMID: 33074588 Objective: To explore contractile actions of angiotensin II (AT2) on the muscularis mucosae (MM) of the bladder.

Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder. Read More »

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