Mule SN, Manchola NC, de Oliveira GS, Pereira M, Magalhães RDM, Teixeira AA, Colli W, Alves MJM, Palmisano G (2021) Proteome-wide modulation of S-nitrosylation in Trypanosoma cruzi trypomastigotes upon interaction with the host extracellular matrix. J Proteomics 231:104020. doi: 10.1016/j.jprot.2020.104020
Objective: To map site-specific S-nitrosylated (SNO) proteins from Trypanosoma cruzi trypomastigotes incubated (MTy) or not (Ty) with extracellular matrix (ECM).
Summary: The results provide the first site-specific characterization of S-nitrosylated proteins in T. cruzi and their modulation upon ECM incubation before infection of the mammalian hosts. The reduction of S-nitrosylation upon incubation with ECM, associated with a rewiring of the subcellular distribution and intracellular signaling pathways, was confirmed.
Usage: Indirect Immunofluorescence Assay (1:250)
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