Author name: Kristen Hartman

Transneuronal tracing from sympathectomized lumbar epaxial muscle in female rats.

Daniels D, Miselis RR, Flanagan-Cato LM (2001) Transneuronal tracing from sympathectomized lumbar epaxial muscle in female rats. J Neurobiol 48(4):278-290. doi: 10.1002/neu.1057 Summary: The authors use pseudorabies virus (PRV) to study central neural networks such as the one controlling the lordosis reflex (increased curvature of the spine). To aid in the separation of the sympathetic […]

Transneuronal tracing from sympathectomized lumbar epaxial muscle in female rats. Read More »

Selective loss of cholinergic neurons projecting to the olfactory system increases perceptual generalization between similar, but not dissimilar, odorants.

Linster C, Garcia PA, Hasselmo ME, Baxter MG (2001) Selective loss of cholinergic neurons projecting to the olfactory system increases perceptual generalization between similar, but not dissimilar, odorants. Behav Neurosci 115(4):826-833. doi: 10.1037//0735-7044.115.4.826 Summary: Selective cholinergic lesioning of the basal forebrain has been linked to attentional and cognitive deficits. 192-Saporin (Cat. #IT-01) was administered to

Selective loss of cholinergic neurons projecting to the olfactory system increases perceptual generalization between similar, but not dissimilar, odorants. Read More »

Normal breathing requires preBotzinger complex neurokinin-1 receptor-expressing neurons.

Gray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL (2001) Normal breathing requires preBotzinger complex neurokinin-1 receptor-expressing neurons. Nat Neurosci 4(9):927-930. doi: 10.1038/nn0901-927 Summary: SP-SAP was effective in eliminating preBötC NK1R neurons in adult rats. Unilateral SP-SAP injection transiently produced sighs (large inspiratory efforts followed by prolonged expiration). Usage: Injections of 0.1–0.2 pmol of SP-SAP

Normal breathing requires preBotzinger complex neurokinin-1 receptor-expressing neurons. Read More »

Selective cholinergic denervation inhibits expression of long-term potentiation in the adult but not infant rat hippocampus.

Motooka Y, Kondoh T, Nomura T, Tamaki N, Tozaki H, Kanno T, Nishizaki T (2001) Selective cholinergic denervation inhibits expression of long-term potentiation in the adult but not infant rat hippocampus. Devel Brain Res 129:119-123. doi: 10.1016/s0165-3806(01)00179-1 Summary: The authors studied the possible role of cholinergic systems in long-term potentiation (LTP), which is one of

Selective cholinergic denervation inhibits expression of long-term potentiation in the adult but not infant rat hippocampus. Read More »

Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the µ-opioid receptor.

Porreca F, Burgess SE, Gardell LR, Vanderah TW, Malan TP Jr, Ossipov MH, Lappi DA, Lai J (2001) Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the µ-opioid receptor. J Neurosci 21(14):5281-5288. doi: 10.1523/JNEUROSCI.21-14-05281.2001 Summary: The presence of descending projections in the pain pathway raises the possibility that abnormal sustained activity

Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the µ-opioid receptor. Read More »

Cover Article: Dermorphin-SAP Kills MOR-Positive Cells

News Article /

Advanced Targeting Systems announces the release of its new, very exciting targeted toxin, dermorphin-SAP. It is a conjugate of the mu opioid receptor (MOR) agonist dermorphin and the ribosome-inactivating protein, saporin. Its cytotoxicity to cells that express the MOR promise to make it an important tool in the discovery and definition of the role of

Cover Article: Dermorphin-SAP Kills MOR-Positive Cells Read More »

Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits.

Browne SE, Lin L, Mattsson A, Georgievska B, Isacson O (2001) Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits. Exp Neurol 170:36-47. doi: 10.1006/exnr.2001.7700 Summary: The authors used 192-Saporin (two 2.5-µg bilateral injections of 1 µg/µl; Cat. #IT-01) to eliminate cholinergic neurons in the rat, then

Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits. Read More »

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