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Normal breathing requires preBotzinger complex neurokinin-1 receptor-expressing neurons.

Gray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL (2001) Normal breathing requires preBotzinger complex neurokinin-1 receptor-expressing neurons. Nat Neurosci 4(9):927-930. doi: 10.1038/nn0901-927

Summary: SP-SAP was effective in eliminating preBötC NK1R neurons in adult rats. Unilateral SP-SAP injection transiently produced sighs (large inspiratory efforts followed by prolonged expiration).

Usage: Injections of 0.1–0.2 pmol of SP-SAP or 0.3 pmol each of unconjugated Saporin and Substance P were made in the pre-BötC.

Related Products: SP-SAP (Cat. #IT-07)

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