Saporin is a 30 kDa protein isolated from the seeds of the plant Saponaria officinalis. This pleasant resident of the banks of Southern European streams has long been known for medicinal properties, mainly due to its saponins, detergents that reside especially in the roots of the plant and which give the plant its name. It […]
Targeting Tools: Saporin – a ribosome-inactivating protein Read More »
Q: What are the options for delivery of targeted toxins? A: The options for toxin delivery are varied and limited only by investigator ingenuity. Generally, injection has been the route of choice. Some toxins can be given intravenously, such as 192-Saporin (192-IgG-SAP, Cat. # IT-01) or anti-DBH-SAP (Cat. # IT-03), in which case all cells
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Lappi DA (2001) Featured Article: Dermorphin-SAP kills MOR-positive cells. Targeting Trends 2(3) Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12) Read the featured article in Targeting Trends.
Featured Article: Dermorphin-SAP kills MOR-positive cells Read More »
Advanced Targeting Systems announces the release of its new, very exciting targeted toxin, dermorphin-SAP. It is a conjugate of the mu opioid receptor (MOR) agonist dermorphin and the ribosome-inactivating protein, saporin. Its cytotoxicity to cells that express the MOR promise to make it an important tool in the discovery and definition of the role of
Cover Article: Dermorphin-SAP Kills MOR-Positive Cells Read More »
Browne SE, Lin L, Mattsson A, Georgievska B, Isacson O (2001) Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits. Exp Neurol 170:36-47. doi: 10.1006/exnr.2001.7700 Summary: The authors used 192-Saporin (two 2.5-µg bilateral injections of 1 µg/µl; Cat. #IT-01) to eliminate cholinergic neurons in the rat, then
Martin JL, Sloviter RS (2001) Focal inhibitory interneuron loss and principal cell hyperexcitability in the rat hippocampus after microinjection of a neurotoxic conjugate of saporin and a peptidase-resistant analog of substance P. J Comp Neurol 436:127-152. doi: 10.1002/cne.1065 Usage: The authors used SSP-SAP (0.4 ng/10 nl; Cat. #IT-11). Related Products: SSP-SAP (Cat. #IT-11) Read the
Speth RC, Grove KL, Brownfield MS (2001) Immunohistochemical localization of AT-1A and AT-1B angiotensin II receptor subtypes in the rat adrenal. Endocrine Society ENDO 2001 – 83rd Annual Meeting of the Endocrine Society, Denver, Colorado. PMID: 909090 Related Products: Angiotensin II receptor (AT-1AR) Rabbit Polyclonal, affinity-purified (Cat. #AB-N25AP)
Cronin CA, Gluba W, Scrable H (2001) The lac operator-repressor system is functional in the mouse. Genes Dev 15(12):1506-1517. doi: 10.1101/gad.892001 PMID: 11410531 Related Products: Antibody to LacI (9A5) (Cat. #AB-V79)
The lac operator-repressor system is functional in the mouse Read More »
Bennett VJ, Simmons MA (2001) Analysis of fluorescently labeled substance P analogs: binding, imaging and receptor activation. BMC Chem Biol 1(1):1. doi: 10.1186/1472-6769-1-1 PMID: 11418083 Related Products: 192-IgG Mouse Monoclonal, Alexa488-labeled (Cat. #AB-N43FLA)
Ferreira G, Meurisse M, Tillet Y, Lévy F (2001) Distribution and co-localization of choline acetyltransferase and p75 neurotrophin receptors in the sheep basal forebrain: implications for the use of a specific cholinergic immunotoxin. Neuroscience 104(2):419-439. doi: 10.1016/s0306-4522(01)00075-6 PMID: 11377845 Summary: ME20.4 is a monoclonal antibody (Cat. #AB-N07) that has been shown to bind the p75