Awarded by ATS at Society for Neuroscience (SFN) San Diego, CA • November 10-15, 2001 410.9 Hypocretin B-Saporin Lesions of the Brainstem Increase REM sleep at night. C.A.Blanco-Centurion*; R.J.Salin-Pascual; D.Gerashchenko; M.A.Greco; P.J.Shiromani featuring IT-20 Orexin-SAP (Poster) Loss of hypocretin (Hcrt) neurons has been linked to narcolepsy. These neurons project widely throughout brain, but it is […]
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Waite JJ, Chen AD (2001) Differential changes in rat cholinergic parameters subsequent to immunotoxic lesion of the basal forebrain nuclei. Brain Res 918:113-120. doi: 10.1016/s0006-8993(01)02968-7 PMID: 11684049 Summary: 192-Saporin (Cat. #IT-01) is used extensively to eliminate the cholinergic neurons of the basal forebrain in rats. Waite and Chen compare the degree of loss between 192-Saporin
Pang KCH, Nocera R, Secor AJ, Yoder RM (2001) GABAergic septohippocampal neurons are not necessary for spatial memory. Hippocampus 11:814-827. doi: 10.1002/hipo.1097 Summary: The medial septum and diagonal band of Broca (MSDB) are necessary for spatial memory. Both cholinergic and GABAergic neuronal populations are present in the MSDB. 192-Saporin (Cat. #IT-01) was used to eliminate
GABAergic septohippocampal neurons are not necessary for spatial memory. Read More »
Berger-Sweeney JE, Stearns NA, Murg SL, Floerke-Nashner LR, Lappi DA, Baxter MG (2001) Selective immunolesions of cholinergic neurons in mice: effects on neuroanatomy, neurochemistry, and behavior. J Neurosci 21(20):8164-8173. doi: 10.1523/JNEUROSCI.21-20-08164.2001 Summary: 192-Saporin (Cat. #IT-01) has long been an effective agent for elimination of cholinergic neurons in the basal forebrain of rats. Until the development
Work on hypocretin, or orexin, as it is also known, is some of the most interesting in all of biology these days. When first characterized a mere three years ago by two groups, it was thought to be involved in feeding (hence the name orexin from the Greek orexis meaning appetite). But two articles exploded
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Q: How long does it take to see the cell death occurring from the use of targeted toxins using saporin? Is there a time course of hours or days? A: Details of the time course of early events have not been extensively studied. After ricin injections into the cervical vagus nerve, the proximal nerve becomes
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Sloviter R (2001) Featured Article: Immunolesioning hippocampal inhibitory interneurons. Targeting Trends 2(4) Related Products: SSP-SAP (Cat. #IT-11), SP-SAP (Cat. #IT-07) Read the featured article in Targeting Trends. See Also: Martin JL et al. Focal inhibitory interneuron loss and principal cell hyperexcitability in the rat hippocampus after microinjection of a neurotoxic conjugate of saporin and a
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On Saturday, September 22, I attended the Tony Mezzadri Surf Contest in Ocean Beach, California. A number of years ago Tony, surfing at the Ocean Beach pier, was paralyzed with no movement in his legs and limited movement in his hands and arms. The Ocean Beach community rose to help Tony and this contest has been
Targeting Article: Surfing to Help Spinal Cord Injuries Read More »
In September, Advanced Targeting Systems received two Small Business Innovation Research (SBIR) awards from the National Institutes of Health. The first is a Phase II grant from the National Institute of Neurological Disorders and Stroke. This project continues a collaboration with Drs. Joanne Berger-Sweeney (Wellesley College) and Mark Baxter (Harvard University) to further develop the
Targeting Article: ATS Receives $900,000 in NIH Funding Read More »
Sinakevitch I, Farris SM, Strausfeld NJ (2001) Taurine-, aspartate- and glutamate-like immunoreactivity identifies chemically distinct subdivisions of Kenyon cells in the cockroach mushroom body. J Comp Neurol 439(3):352-367. doi: 10.1002/cne.1355 PMID: 11596059 Related Products: L-Glutamate Rabbit Polyclonal, Conjugated (Cat. #AB-T08), L-Glutamate Mouse Monoclonal, Conjugated (Cat. #AB-T12), D-Glutamic Acid (D-Glutamate) Rabbit Polyclonal, Conjugated (Cat. #AB-T045)