Author name: Kristen Hartman

Effects of hypocretin-saporin injections into the medial septum on sleep and hippocampal theta.

Gerashchenko D, Salin-Pascual R, Shiromani PJ (2001) Effects of hypocretin-saporin injections into the medial septum on sleep and hippocampal theta. Brain Res 913:106-115. doi: 10.1016/s0006-8993(01)02792-5 Summary: Hypocretin, also known as orexin, neurons are located only in the lateral hypothalamus. Recently, the loss of these neurons was shown to be associated with narcolepsy. The authors used […]

Effects of hypocretin-saporin injections into the medial septum on sleep and hippocampal theta. Read More »

Extensive immunolesions of basal forebrain cholinergic system impair offspring recognition in sheep.

Ferreira G, Meurisse M, Gervais R, Ravel N, Levy F (2001) Extensive immunolesions of basal forebrain cholinergic system impair offspring recognition in sheep. Neuroscience 106(1):103-116. doi: 10.1016/s0306-4522(01)00265-2 Summary: Through the use of 192-Saporin (Cat. #IT-01) the association of basal forebrain cholinergic neurons to learning instrumental tasks has been well established in the rat. The authors

Extensive immunolesions of basal forebrain cholinergic system impair offspring recognition in sheep. Read More »

Hippocampal sympathetic ingrowth occurs following 192-IgG-saporin administration.

Harrell LE, Parsons D, Kolasa K (2001) Hippocampal sympathetic ingrowth occurs following 192-IgG-saporin administration. Brain Res 911:158-162. doi: 10.1016/s0006-8993(01)02626-9 Summary: Electrolytic lesions of the medial septal region in rats cause peripheral sympathetic fibers from the superior cervical ganglia to grow into the cholinergically-denervated areas of the hippocampus. This lesioning method is non-specific and disrupts several

Hippocampal sympathetic ingrowth occurs following 192-IgG-saporin administration. Read More »

Dissociation between the attentional functions mediated via basal forebrain cholinergic and GABAergic neurons.

Burk JA, Sarter M (2001) Dissociation between the attentional functions mediated via basal forebrain cholinergic and GABAergic neurons. Neuroscience 105(4):899-909. doi: 10.1016/s0306-4522(01)00233-0 Summary: The specificity and efficacy of 192-Saporin (Cat. #IT-01) has allowed the extensive investigation of cortical cholinergic inputs in attentional functions. Little is known about the function of non-cholinergic neurons because of the

Dissociation between the attentional functions mediated via basal forebrain cholinergic and GABAergic neurons. Read More »

Transneuronal tracing from sympathectomized lumbar epaxial muscle in female rats.

Daniels D, Miselis RR, Flanagan-Cato LM (2001) Transneuronal tracing from sympathectomized lumbar epaxial muscle in female rats. J Neurobiol 48(4):278-290. doi: 10.1002/neu.1057 Summary: The authors use pseudorabies virus (PRV) to study central neural networks such as the one controlling the lordosis reflex (increased curvature of the spine). To aid in the separation of the sympathetic

Transneuronal tracing from sympathectomized lumbar epaxial muscle in female rats. Read More »

Selective loss of cholinergic neurons projecting to the olfactory system increases perceptual generalization between similar, but not dissimilar, odorants.

Linster C, Garcia PA, Hasselmo ME, Baxter MG (2001) Selective loss of cholinergic neurons projecting to the olfactory system increases perceptual generalization between similar, but not dissimilar, odorants. Behav Neurosci 115(4):826-833. doi: 10.1037//0735-7044.115.4.826 Summary: Selective cholinergic lesioning of the basal forebrain has been linked to attentional and cognitive deficits. 192-Saporin (Cat. #IT-01) was administered to

Selective loss of cholinergic neurons projecting to the olfactory system increases perceptual generalization between similar, but not dissimilar, odorants. Read More »

Normal breathing requires preBotzinger complex neurokinin-1 receptor-expressing neurons.

Gray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL (2001) Normal breathing requires preBotzinger complex neurokinin-1 receptor-expressing neurons. Nat Neurosci 4(9):927-930. doi: 10.1038/nn0901-927 Summary: SP-SAP was effective in eliminating preBötC NK1R neurons in adult rats. Unilateral SP-SAP injection transiently produced sighs (large inspiratory efforts followed by prolonged expiration). Usage: Injections of 0.1–0.2 pmol of SP-SAP

Normal breathing requires preBotzinger complex neurokinin-1 receptor-expressing neurons. Read More »

Selective cholinergic denervation inhibits expression of long-term potentiation in the adult but not infant rat hippocampus.

Motooka Y, Kondoh T, Nomura T, Tamaki N, Tozaki H, Kanno T, Nishizaki T (2001) Selective cholinergic denervation inhibits expression of long-term potentiation in the adult but not infant rat hippocampus. Devel Brain Res 129:119-123. doi: 10.1016/s0165-3806(01)00179-1 Summary: The authors studied the possible role of cholinergic systems in long-term potentiation (LTP), which is one of

Selective cholinergic denervation inhibits expression of long-term potentiation in the adult but not infant rat hippocampus. Read More »

Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the µ-opioid receptor.

Porreca F, Burgess SE, Gardell LR, Vanderah TW, Malan TP Jr, Ossipov MH, Lappi DA, Lai J (2001) Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the µ-opioid receptor. J Neurosci 21(14):5281-5288. doi: 10.1523/JNEUROSCI.21-14-05281.2001 Summary: The presence of descending projections in the pain pathway raises the possibility that abnormal sustained activity

Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the µ-opioid receptor. Read More »

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