Q: How long does it take to see the cell death occurring from the use of targeted toxins using saporin? Is there a time course of hours or days? A: Details of the time course of early events have not been extensively studied. After ricin injections into the cervical vagus nerve, the proximal nerve becomes […]
Time Course of Targeted Toxins Read More »
Sloviter R (2001) Featured Article: Immunolesioning hippocampal inhibitory interneurons. Targeting Trends 2(4) Related Products: SSP-SAP (Cat. #IT-11), SP-SAP (Cat. #IT-07) Read the featured article in Targeting Trends. See Also: Martin JL et al. Focal inhibitory interneuron loss and principal cell hyperexcitability in the rat hippocampus after microinjection of a neurotoxic conjugate of saporin and a
Featured Article: Immunolesioning hippocampal inhibitory interneurons Read More »
On Saturday, September 22, I attended the Tony Mezzadri Surf Contest in Ocean Beach, California. A number of years ago Tony, surfing at the Ocean Beach pier, was paralyzed with no movement in his legs and limited movement in his hands and arms. The Ocean Beach community rose to help Tony and this contest has been
Targeting Article: Surfing to Help Spinal Cord Injuries Read More »
In September, Advanced Targeting Systems received two Small Business Innovation Research (SBIR) awards from the National Institutes of Health. The first is a Phase II grant from the National Institute of Neurological Disorders and Stroke. This project continues a collaboration with Drs. Joanne Berger-Sweeney (Wellesley College) and Mark Baxter (Harvard University) to further develop the
Targeting Article: ATS Receives $900,000 in NIH Funding Read More »
Sinakevitch I, Farris SM, Strausfeld NJ (2001) Taurine-, aspartate- and glutamate-like immunoreactivity identifies chemically distinct subdivisions of Kenyon cells in the cockroach mushroom body. J Comp Neurol 439(3):352-367. doi: 10.1002/cne.1355 PMID: 11596059 Related Products: L-Glutamate Rabbit Polyclonal, Conjugated (Cat. #AB-T08), L-Glutamate Mouse Monoclonal, Conjugated (Cat. #AB-T12), D-Glutamic Acid (D-Glutamate) Rabbit Polyclonal, Conjugated (Cat. #AB-T045)
Dr. Robert Sloviter, University of Arizona, contributes this issue’s article from the laboratories of ATS customers. Dr. Sloviter summarizes his research with SSP-saporin, which he and his graduate student Jennifer Martin used to examine the role of inhibitory neurons in maintaining normal network excitability. The mammalian hippocampus is perhaps the most intensely studied brain region
Cover Article: Immunolesioning Hippocampal Inhibitory Interneurons Read More »
Kanai T, Watanabe M, Okazawa A, Sato T, Yamazaki M, Okamoto S, Ishii H, Totsuka T, Iiyama R, Okamoto R, Ikeda M, Kurimoto M, Takeda K, Akira S, Hibi T (2001) Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease. Gastroenterol 121:875-888. doi: 10.1053/gast.2001.28021 Summary: Crohn’s disease is an inflammatory bowel disease that
Ries A, Göhring W, Fox JW, Timpl R, Sasaki T (2001) Recombinant domains of mouse nidogen-1 and their binding to basement membrane proteins and monoclonal antibodies. Eur J Biochem 268(19):5119-5128. doi: 10.1046/j.0014-2956.2001.02437.x PMID: 11589703 Related Products: Antibody to Nidogen, G1 [JF1 (1F1-F5-A10)] (Cat. #AB-V32), Antibody to Nidogen, G3 [JF2 (1E2-A5-A3)] (Cat. #AB-V33), Antibody to Nidogen,
Jasmin L, Ohara PT (2001) Long-term intrathecal catheterization in the rat. J Neurosci Methods 110:81-89. doi: 10.1016/s0165-0270(01)00420-4 Summary: The authors have developed a method that allows repeated administration of drugs with minimal stress to an experimental animal. To test the efficacy of this intrathecal catheter, they injected anti-DBH-SAP (5 µg; Cat. #IT-03,) and investigated the
Long-term intrathecal catheterization in the rat. Read More »
Gerashchenko D, Kohls MD, Greco M, Waleh NS, Salin-Pascual R, Kilduff TS, Lappi DA, Shiromani PJ (2001) Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat. J Neurosci 21(18):7273-7283. doi: 10.1523/JNEUROSCI.21-18-07273.2001 PMID: 11549737 Summary: Orexin (also knows as hypocretin) peptides are produced exclusively by neurons in the lateral hypothalamus, however non-specific