Fang J, Sia J, Soto J, Wang P, Li LK, Hsueh YY, Sun R, Faull KF, Tidball JG, Li S (2021) Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro. Nat Biomed Eng 5(8):864-879. doi: 10.1038/s41551-021-00696-y PMID: 33737730 Objective: To show that myogenic stem cells expanded […]
Eu WZ, Chen YJ, Chen WT, Wu KY, Tsai CY, Cheng SJ, Carter RN, Huang GJ (2021) The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation. Transl Psychiatry 11(1):162. doi: 10.1038/s41398-021-01280-3 Objective: To determine whether the supportive effect of NGF on learning and memory is specifically dependent upon intact
Wensley HJ, Smith WS, Holmes SE, Flavell SU, Flavell DJ (2021) The effect of small molecule pharmacological agents on the triterpenoid saponin induced endolysosomal escape of saporin and a saporin-based immunotoxin in target human lymphoma cells. Biomedicines 9(3):300. doi: 10.3390/biomedicines9030300 Summary: Triterpenoid saponins augment the cytotoxicity of saporin based immunotoxins. It is postulated that this
Brodie-Kommit J, Clark BS, Shi Q, Shiau F, Kim DW, Langel J, Sheely C, Ruzycki PA, Fries M, Javed A, Cayouette M, Schmidt T, Badea T, Glaser T, Zhao H, Singer J, Blackshaw S, Hattar S (2021) Atoh7-independent specification of retinal ganglion cell identity. Sci Adv 7(11):eabe4983. doi: 10.1126/sciadv.abe4983 PMID: 33712461 Related Products: Melanopsin Rabbit
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Sato M, Saitoh I, Akasaka E, Inada E (2021) Development of a novel pipette tip-aided cell cloning method for the effective isolation of genome-edited porcine cell. OBM Genetics 5(1):16. doi: 10.21926/obm.genet.2101126 Summary: Isolation of clonal cells from a single colony is an essential step in the process of obtaining pure populations of stably-transfected clones after
Geraghty T, Winter DR, Miller RJ, Miller RE, Malfait AM (2021) Neuroimmune interactions and osteoarthritis pain: focus on macrophages. Pain Rep 6(1):e892. doi: 10.1097/PR9.0000000000000892 Summary: The contribution of macrophages to osteoarthritis (OA) joint damage has garnered much attention in recent years. The authors discuss how macrophages participate in the initiation and maintenance of pain in
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Andriessen AS, Donnelly CR, Ji RR (2021) Reciprocal interactions between osteoclasts and nociceptive sensory neurons in bone cancer pain. Pain Rep 6(1):e867. doi: 10.1097/PR9.0000000000000867 Summary: Current pharmacotherapies available for bone cancer pain are insufficient to provide safe and efficacious pain relief. The authors discuss the mechanisms used by cancer cells within the bone tumor microenvironment
Masoumi KC, Huang X, Sime W, Mirkov A, Munksgaard Thorén M, Massoumi R, Lundgren-Åkerlund E (2021) Integrin α10-antibodies reduce glioblastoma tumor growth and cell migration. Cancers (Basel) 13(5):1184. doi: 10.3390/cancers13051184 Summary: The authors investigated the treatment effect of two antibodies that have been developed to target the protein integrin 10, which is present on the
Integrin α10-antibodies reduce glioblastoma tumor growth and cell migration Read More »
Shen Q, Xu L, Li R, Wu G, Li S, Saw PE, Zhou Y, Xu X (2021) A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy. Chem Commun (Camb) 57(20):2563-2566. doi: 10.1039/d0cc07808e Summary: This publication describes the development of a robust nanoplatform made with a TME-pH responsive Meo-PEG-b-PPMEMA polymer and
Ebadi R, Rabiee F, Kordi-Tamandani D, Nasr-Esfahani MH, Ghaedi K (2021) Fndc5 knockdown significantly decreased the expression of neurotrophins and their respective receptors during neural differentiation of mouse embryonic stem cells. Hum Cell 34(3):847-861. doi: 10.1007/s13577-021-00517-z PMID: 33683654 Objective: To evaluate whether knockdown of Fibronectin type III domain-containing-5 (Fndc5) decreases neural differentiation of mouse embryonic