Borkowski LF, Smith CL, Keilholz AN, Nichols NL (2021) Divergent receptor utilization is necessary for phrenic long-term facilitation over the course of motor neuron loss following CTB-SAP intrapleural injections. J Neurophysiol 126(3):709-722. doi: 10.1152/jn.00236.2021
Objective: The authors tested the hypothesis that phrenic long-term facilitation (pLTF) following treatment with CTB-SAP is: 1) adenosine 2A (A2A) receptor-dependent at 7d; and 2) serotonin (5-HT) receptor-dependent at 28d.
Summary: This study furthers understanding of the contribution of differential receptor activation to pLTF and its implications for breathing following respiratory motor neuron death.
Usage: Male rats received bilateral, intrapleural injections of CTB-SAP or Saporin Control (25 μg).