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Acetylcholine from the nucleus basalis magnocellularis facilitates the retrieval of well-established memory

Soma S, Suematsu N, Sato AY, Tsunoda K, Bramian A, Reddy A, Takabatake K, Karube F, Fujiyama F, Shimegi S (2021) Acetylcholine from the nucleus basalis magnocellularis facilitates the retrieval of well-established memory. Neurobiol Learn Mem 183:107484. doi: 10.1016/j.nlm.2021.107484

Summary: The authors tested the effect of a cholinesterase inhibitor, donepezil, on the retrieval of memory after a long no-task period in extensively trained rats. The results suggest that acetylcholine released from the NBM contributes to the retrieval of well-established memory developed by a daily routine.

Usage: Cholinergic neurons of the nucleus basalis magnocellularis (NBM) were lesioned with 192-IgG-SAP. NBM-lesioned rats showed severely impaired task initiation and performance. These abilities recovered as the trials progressed, though they never reached the level observed in rats with intact NBM. Saline with or without 192-IgG-SAP (0.3 μg in 1 μL, per site) was bilaterally injected into 2 sites of the NBM.

Related Products: 192-IgG-SAP (Cat. #IT-01)