Truitt WA, McKenna KE, Coolen LM (2002) Lesions of spinothalamic neurons in lumbar spinal cord disrupt ejaculatory reflexes in male rats. Neuroscience 2002 Abstracts 69.2. Society for Neuroscience, Orlando, FL. Summary: Previously we tested the significance of a population of lumbar spinothalamic (LUST) cells for male sexual behavior in rats. Anatomically, LUST cells are positioned […]
Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH (2002) Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci 5(12):1319-1326. doi: 10.1038/nn966 Related Products: SP-SAP (Cat. #IT-07)
Tokuno H, Chiken S, Kametani K, Moriizumi T (2002) Efferent projections from the striatal patch compartment: anterograde degeneration after selective ablation of neurons expressing mu-opioid receptor in rats. Neurosci Lett 332(1):5-8. doi: 10.1016/s0304-3940(02)00837-6 Summary: Taking advantage of the fact that neurons in patch compartments of the striatum express µ-opioid receptors, the authors injected 8.5 ng
Khasabov SG, Rogers SD, Ghilardi JR, Peters CM, Mantyh PW, Simone DA (2002) Spinal neurons that possess the substance P receptor are required for the development of central sensitization. J Neurosci 22(20):9086-9098. doi: 10.1523/JNEUROSCI.22-20-09086.2002 Summary: Using 5 x 10-5 M intrathecal injections of SP-SAP (Cat. #IT-07) the authors examined the role of SPR-expressing neurons in
Bechade C, Mallecourt C, Sedel F, Vyas S, Triller A (2002) Motoneuron-derived neurotrophin-3 is a survival factor for PAX2-expressing spinal interneurons. J Neurosci 22(20):8779-8784. doi: 10.1523/JNEUROSCI.22-20-08779.2002 Summary: In the rat, half of motoneurons die between embryonic day 15 and postnatal day 1. Programmed cell death of interneurons is not as well characterized. The authors cultured
Q: How do I know my antibody will work in an immunotoxin? A: We recommend that you use one of our second immunotoxins (secondary conjugates) to test for specificity and internalization of your antibody. Q: How much antibody do I need to provide for a custom conjugation? A: The required quantity is 8-15 mg of
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Cassel JC (2002) Featured Article: Does 192-IgG-Saporin or 5,7-DHT kill cognitive functions in the rat?. Targeting Trends 3(4) Related Products: 192-IgG-SAP (Cat. #IT-01) Read the featured article in Targeting Trends. See Also: Lehmann O et al. 5,7-DHT-induced hippocampal 5-HT depletion attenuates behavioural deficits produced by 192 IgG-saporin lesions of septal cholinergic neurons in the rat.
Featured Article: Does 192-IgG-Saporin or 5,7-DHT kill cognitive functions in the rat? Read More »
Zeitschel U, Schliebs R, Rossner S, Bigl V, Eschrich K, Bigl M (2002) Changes in activity and expression of phosphofructokinase in different rat brain regions after basal forebrain cholinergic lesion. J Neurochem 83(2):371-380. doi: 10.1046/j.1471-4159.2002.01127.x Summary: The authors used intraventricular injections of 4 µg of 192-Saporin (Cat. #IT-01) in rats to investigate whether impaired cholinergic
Contributed by Jean-Christophe Cassel, PhD, Laboratoire de Neurosciences Cognitives et Comportementales, UMR 7521 Université Louis Pasteur/CNRS, Strasbourg, France & Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Freiburg, Germany. Dr. Cassel and colleagues are the authors of four publications released this quarter using 192-Saporin (Cat. #IT-01) Trying to understand how
Cover Article: Does 192-IgG-Saporin or 5,7-DHT kill cognitive functions in the rat? Read More »
Ballmaier M, Casamenti F, Scali C, Mazzoncini R, Zoli M, Pepeu G, Spano PF (2002) Rivastigmine antagonizes deficits in prepulse inhibition induced by selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis. Neuroscience 114(1):91-98. doi: 10.1016/s0306-4522(02)00234-8 Summary: The authors injected 300 nl of 400 ng/ml 192-Saporin (Cat. #IT-01) bilaterally into the nucleus basalis magnocellularis of