pHast Conjugates, Fast Tools
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Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta)
Nazmuddin M, Stammes MA, Klink PC, Vernes MK, Bakker J, Langermans JAM, van Laar T, Philippens IHCHM (2025) Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta). J Neuropathol Exp Neurol nlaf081. doi: 10.1093/jnen/nlaf081 PMID: 40673943 Objective: To describe a procedure to
Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats
Noble EE, Harris RBS (2025) Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats. Am J Physiol Endocrinol Metab 329(1):E1-E17. doi: 10.1152/ajpendo.00090.2025 PMID: 40418155 Objective: To determine whether leptin receptor–expressing neurons in the ventromedial hypothalamus (VMH) contribute to the initial overconsumption of a high-fat diet in rats. Summary: Ablation of
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Disease-Modeling Saporin Conjugates
Product Disease Model 192-IgG-SAP (Cat. #IT-01) Alzheimer’s Disease Acetylated LDL-SAP (Cat. #IT-08) Alzheimer’s Disease Anti-ChAT-SAP (Cat. #IT-42) Alzheimer’s Disease, Down syndrome, Rett syndrome Anti-DAT-SAP (Cat. #IT-25) Parkinson’s Disease Anti-DBH-SAP (Cat. #IT-03) Alzheimer’s Disease CTB-SAP (Cat. #IT-14) Lou Gehrig’s Disease (Amyotrophic lateral sclerosis, ALS) GAT1-SAP (Cat. #IT-32) Epilepsy Mac-1-SAP mouse/human (Cat. #IT-06) Alzheimer’s Disease ME20.4-SAP (Cat.
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Saporin as the Scalpel
Saporin as the Scalpel The Proxima recently hosted a 2-day joint conference on Dementia, Alzheimer’s and Parkinson’s diseases (DAPD-2025) and Neurodegenerative & Neuromuscular diseases (NND-2025). The hybrid conferences took place in the beautiful city of Barcelona, Spain and online during June 19-20, 2025. As authors of the publication, “Saporin as a Commercial Reagent: Its Uses
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Influence of neurokinin b, dynorphin a and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes
Szysiak N, Kosior-Korzecka U, longo V, Patkowski K, Greguła-Kania M, Nowakiewicz A, Bochniarz M,Junkuszew A (2025) Influence of neurokinin b, dynorphin a and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes. J Vet Res doi: 10.2478/jvetres-2025-0003 Objective: The aim of the study was to analyze the direct effect of
Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats
Orciani C, Foret MK, Cuello AC, Carmo SD (2025) Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats. Neurobiology of Aging 150:132-145. doi: 10.1016/j.neurobiolaging.2025.03.006 PMID: 40121723 Objective: To investigate the effects of the Basal forebrain cholinergic neurons (BFCNs) input on neurovascular unit (NVU) components. Summary: