Kristen Hartman – Page 4 – Advanced Targeting Systems

A non-invasive stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice

Bryder D, Konturk-Ciesla A, Zhang Q, Kharazi S (2024) A non-invasive stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice. Research Square doi: 10.21203/rs.3.rs-4528815/v1 Objective: To develop a murine transplantation model based on low-intensity conditioning protocols using antibody-mediated Hematopoietic stem cell. Summary: Authors demonstrate that young HSCs, once transplanted, survive and thrive […]

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Mitigating the functional deficit after neurotoxic motoneuronal loss by an inhibitor of mitochondrial fission

Kristen Hartman

Ciuro M, Sangiorgio M, Cacciato V, Cantone G, Fichera C, Salvatorelli L, Magro G, Leanza G, Vecchio M, Valle MS, Gulino R (2024) Mitigating the functional deficit after neurotoxic motoneuronal loss by an inhibitor of mitochondrial fission. Int J Mol Sci 25(13):7059. doi: 10.3390/ijms25137059 PMID: 39000168 Objective: To use the Cholera Toxin B-Saporin (CTB-SAP) mouse

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Approach/avoidance behavior to novel objects is correlated with the serotonergic and dopaminergic systems in the brown rat (rattus norvegicus)

Kristen Hartman

Kiyokawa Y, Ootaki M, Kambe Y, Tanaka KD, Kimura G, Tanikawa T, Takeuchi Y (2024) Approach/avoidance behavior to novel objects is correlated with the serotonergic and dopaminergic systems in the brown rat (rattus norvegicus). Neuroscience 549:110-120. doi: 10.1016/j.neuroscience.2024.05.003 PMID: 38723837 Objective: To compare the dopaminergic, serotonergic, and noradrenergic systems immunohistochemically among rats. Summary: The serotonergic

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Selective haematological cancer eradication with preserved haematopoiesis

Kristen Hartman

Garaudé S, Marone R, Lepore R, Devaux A, Beerlage A, Seyres D, Dell’ Aglio A, Juskevicius D, Zuin J, Burgold T, Wang S, Katta V, Manquen G, Li Y, Larrue C, Camus A, Durzynska I, Wellinger LC, Kirby I, Van Berkel PH, Kunz C, Tamburini J, Bertoni F, Widmer CC, Tsai SQ, Simonetta F, Urlinger

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Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of Simian immunodeficiency virus

Kristen Hartman

Simpson J, Starke CE, Ortiz AM, Ransier A, Darko S, Llewellyn-Lacey S, Fennessey CM, Keele BF, Douek DC, Price DA, Brenchley JM (2024) Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of Simian immunodeficiency virus. JCI Insight e174168. doi: 10.1172/jci.insight.174168 PMID: 38885329 Objective: To investigate the role of gag epitope-specific CD8+ T cells

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Retinal ganglion cell type-specific expression of synuclein family members revealed by scRNA-sequencing

Kristen Hartman

Yang Q, Liu L, He F, Zhao W, Chen Z, Wu X, Rao B, Lin X, Mao F, Qu J, Zhang J (2024) Retinal ganglion cell type-specific expression of synuclein family members revealed by scRNA-sequencing. Int J Med Sci 21(8):1472-1490. doi: 10.7150/ijms.95598 Objective: To analyze the single-cell transcriptome in healthy and injured retinas to investigate

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Cholinergic modulation of dopamine-related effects of ethanol in the rat

Kristen Hartman

Loften A (2024) Cholinergic modulation of dopamine-related effects of ethanol in the rat. Univ Gothenburg Thesis. Objective: To explore the role of acetylcholine and cholinergic interneurons (CIN) in ethanol-induced dopamine (DA) release and in the reinforcing effects of ethanol. Summary: The author’s thesis supports an important role of accumbal CIN in ethanol ́s DA releasing

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Do Fab-ZAPs tell us what mAbs internalize best?

Kristen Hartman

Question: Hello, I am very interested in using your Fab-ZAP line. So Fab-ZAPs simply tells us what mAbs internalize best – is that right? Can you send me some example data? I’d love to see a cell line that has been evaluated and the data that has been generated. Answer: Yes, Fab-ZAPs will tell you

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Where does the saporin payload release after internalization?

Kristen Hartman

Question: Where does the saporin payload release after internalization? For example, does it require trafficking into a late endosome/lysosomal compartment? Answer: Thank you for reaching out to us. Hopefully I can help answer some of your questions regarding what happens to saporin after being internalized. I would first like to refer you to an article we

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Cardiorespiratory disturbances in Alzheimer’s disease: A focus on the contribution of sympathetic premotor neurons

Kristen Hartman

Toledo C, Del Rio R (2024) Cardiorespiratory disturbances in Alzheimer’s disease: A focus on the contribution of sympathetic premotor neurons. Am Physiol Summit 39(S1) doi: 10.1152/physiol.2024.39.S1.2540 Objective: To characterize cardiorespiratory function in AD patients and then to determine the role of RVLM-C1 neurons in autonomic and sleep-disordered breathing in APP/PS1 double transgenic mice, and experimental

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Author name: Kristen Hartman