Author name: Kristen Hartman

The amygdala modulates the consolidation of memories of emotionally arousing experiences

McGaugh JL (2004) The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annu Rev Neurosci 27:1-28. doi: 10.1146/annurev.neuro.27.070203.144157 Objective: This review focuses primarily on the findings of research investigating the role of the amygdala in modulating the consolidation of long-term memories. Summary: The activation of neuromodulatory systems affecting the BLA and its projections […]

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Selective cholinergic denervation of the cingulate cortex impairs the acquisition and performance of a conditional visual discrimination in rats.

Winters BD, Robbins TW, Everitt BJ (2004) Selective cholinergic denervation of the cingulate cortex impairs the acquisition and performance of a conditional visual discrimination in rats. Eur J Neurosci 19(2):490-496. doi: 10.1111/j.0953-816x.2003.03157.x Summary: Performance in conditional discrimination tasks is thought to be controlled at least in part by the cingulate cortex and its basal forebrain

Selective cholinergic denervation of the cingulate cortex impairs the acquisition and performance of a conditional visual discrimination in rats. Read More »

Impaired and spared cholinergic functions in the hippocampus after lesions of the medial septum/vertical limb of the diagonal band with 192 IgG-saporin.

Chang Q, Gold PE (2004) Impaired and spared cholinergic functions in the hippocampus after lesions of the medial septum/vertical limb of the diagonal band with 192 IgG-saporin. Hippocampus 14(2):170-179. doi: 10.1002/hipo.10160 Summary: 192-Saporin has been widely used to eliminate cholinergic neurons in the basal forebrain. These lesions can produce near-total loss of choline acetyltranferase (ChAT)-positive

Impaired and spared cholinergic functions in the hippocampus after lesions of the medial septum/vertical limb of the diagonal band with 192 IgG-saporin. Read More »

Targeting Tools: Somatostatin Receptor Targeting

Advanced Targeting Systems is pleased to announce the availability of polyclonal antibodies to somatostatin receptor (SSTr) sub-types 1 and 4. SSTr1 antiserum, Cat. #AB-N19 SSTr1 affinity-purified, Cat. #AB-N20AP SSTr4 affinity-purified, Cat. #AB-N21AP Antibody to SSTr1 SSTr1 is a 391 amino acid G-protein-coupled receptor that contains three glycosylation sites and that is expressed in several areas

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Not the Right Stuff

Q: Are all lots of 192-Saporin (192-IgG-SAP, Cat. #IT-01) the same? A: There are variances from lot to lot, and Advanced Targeting Systems includes a cytotoxicity graph on the data sheet with each product comparing the current lot with previous lots. Chemicon International also sells immunotoxins, and used to distribute ATS products. However, since early

Not the Right Stuff Read More »

Septohippocampal acetylcholine: involved in but not necessary for learning and memory?

Parent MB, Baxter MG (2004) Septohippocampal acetylcholine: involved in but not necessary for learning and memory?. Learn Mem 11:9-20. doi: 10.1101/lm.69104 Summary: In this review the authors describe some of the methods and rationale behind the investigation of hippocampal acetylcholine and its role in the support of learning and memory processes. Results produced by the

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Involvement of cholinergic neuronal systems in intravenous cocaine self-administration.

Smith JE, Co C, Yin X, Sizemore GM, Liguori A, Johnson WE 3rd, Martin TJ (2004) Involvement of cholinergic neuronal systems in intravenous cocaine self-administration. Neurosci Biobehav Rev 27(8):841-850. doi: 10.1016/j.neubiorev.2003.11.002 Summary: Recent studies have demonstrated that cholinergic neurons take part in the process of cocaine self-administration. In this study the authors used 0.25 µg-injections

Involvement of cholinergic neuronal systems in intravenous cocaine self-administration. Read More »

Featured Article: Cholinergic deafferentation of the entorhinal cortex impairs working memory for novel, but not familiar stimuli in a delayed non-match to sample (DNMS) task

McGaughy J (2004) Featured Article: Cholinergic deafferentation of the entorhinal cortex impairs working memory for novel, but not familiar stimuli in a delayed non-match to sample (DNMS) task. Targeting Trends 5(1) Related Products: 192-IgG-SAP (Cat. #IT-01) Read the featured article in Targeting Trends. See Also: McGaughy JA et al. Cholinergic deafferentation of the entorhinal cortex

Featured Article: Cholinergic deafferentation of the entorhinal cortex impairs working memory for novel, but not familiar stimuli in a delayed non-match to sample (DNMS) task Read More »

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