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Exogenous testosterone prevents motoneuron atrophy induced by contralateral motoneuron depletion.

Fargo KN, Sengelaub DR (2004) Exogenous testosterone prevents motoneuron atrophy induced by contralateral motoneuron depletion. J Neurobiol 60(3):348-359. doi: 10.1002/neu.20027

Summary: Gonadal steroids have been shown to supply a variety of neuroprotective and neurotherapeutic effects. Using 1-┬Ál injections of 0.1% CTB-SAP (Cat. #IT-14) into the ipsalateral bulbocavernosus and the levator ani of rats, the authors examined the protective effects of testosterone on motoneuron morphology. After the lesion was induced some rats were castrated, and all animals were treated with exogenous testosterone. The results suggest that high-normal levels of testosterone can prevent motoneuron atrophy induced by contralateral motoneuron depletion.

Related Products: CTB-SAP (Cat. #IT-14)

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