As most of you know, SP-SAP is a potential therapeutic that ATS is developing for use in the elimination of chronic pain. For the past seven years, preclinical studies have been carried out in the rat, safety and dosing studies completed in the dog and the first of two toxicology studies has begun in the […]
SP-SAP: How It’s Different From Substance P Antagonists Read More »
Contributed by Lesley E. Northrop, Nicole Cameron and Mary Erskine, Department of Biology, Boston University The posterodorsal medial amygdala (MePD) is involved in processing the information from genito- sensory stimuli which is needed for mating-induced pseudopregnancy. The amygdala complex is known to be involved in memory storage and consolidation, processes known to be influenced by
Mothet JP, Pollegioni L, Ouanounou G, Martineau M, Fossier P, Baux G (2005) Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine. Proc Natl Acad Sci U S A 102(15):5606-5611. doi: 10.1073/pnas.0408483102 PMID: 15800046 Related Products: D-Serine Rabbit Polyclonal, Conjugated (Cat. #AB-T048)
Ross RS, McGaughy J, Eichenbaum H (2005) Acetylcholine in the orbitofrontal cortex is necessary for the acquisition of a socially transmitted food preference. Learn Mem 12(3):302-306. doi: 10.1101/lm.91605 Summary: Cortical involvement in social transmission of food preference (STFP) has not been established, but the importance of the orbitofrontal cortex (OFC) in odor-guided learning is known.
Pagliardini S, Adachi T, Ren J, Funk GD, Greer JJ (2005) Fluorescent tagging of rhythmically active respiratory neurons within the pre-Bötzinger complex of rat medullary slice preparations. J Neurosci 25:2591-2596. doi: 10.1523/JNEUROSCI.4930-04.2005 PMID: 15758169 Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)
Chiken S, Tokuno H (2005) Impairment of skilled forelimb use after ablation of striatal interneurons expressing substance P receptors in rats: an analysis using a pasta matrix reaching task. Exp Brain Res 162(4):532-536. doi: 10.1007/s00221-004-2189-2 Summary: The substance P receptor is expressed by two types of interneurons in the striatum. The authors investigated whether elimination
Dudkin KN, Chueva V, Makarov FN, Bich TG, Roer AE (2005) Impairments in working memory and decision-taking processes in monkeys in a model of Alzheimer’s disease. Neurosci Behav Physiol 35(3):281-289. PMID: 15875490 Related Products: ME20.4-SAP (Cat. #IT-15), Anti-DBH-SAP (Cat. #IT-03)
Bugarith K, Dinh TT, Li AJ, Speth RC, Ritter S (2005) Basomedial hypothalamic injections of neuropeptide Y conjugated to saporin selectively disrupt hypothalamic controls of food intake. Endocrinology 146(3):1179-1191. doi: 10.1210/en.2004-1166 Summary: The authors examined the effect of 48 ng injections of NPY-SAP (Cat. #IT-28) into the basomedial hypothalamus (BMH) on glucoprivic feeding in rats.
Seki S, Erickson KA, Seki M, Nishizawa O, Igawa Y, Ogawa T, de Groat WC, Chancellor MB, Yoshimura N (2005) Elimination of rat spinal neurons expressing neurokinin 1 receptors reduces bladder overactivity and spinal c-fos expression induced by bladder irritation. Am J Physiol Renal Physiol 288(3):F466-F473. doi: 10.1152/ajprenal.00274.2004 Summary: Substance P is reported to play
Craig ML, Waitumbi JN, Taylor RP (2005) Processing of C3b-opsonized immune complexes bound to non-complement receptor 1 (CR1) sites on red cells: phagocytosis, transfer, and associations with CR1. J Immunol 174(5):3059-3066. doi: 10.4049/jimmunol.174.5.3059 PMID: 15728520 Related Products: Antibody to Complement receptor 1 (CR1) (7G9) (Cat. #AB-V25)