Gerashchenko D, Murillo-Rodriguez E, Blanco-Centurion C, Lin L, Nishino S, Mignot E, Shiromani PJ (2005) Adenosine levels do not increase with 6 h waking in rats with lesions of the lateral hypothalamus. Neuroscience 2005 Abstracts 63.9. Society for Neuroscience, Washington, DC. Summary: The hypocretin neurons in the lateral hypothalamus (LH) have been implicated in wakefulness, […]
Gerashchenko D, Blanco-Centurion CA, Miller JD, Shiromani PJ (2006) Insomnia following hypocretin2-saporin lesions of the substantia nigra. Neuroscience 137(1):29-36. doi: 10.1016/j.neuroscience.2005.08.088 Objective: To investigate which regions of major arousal areas might be responsible for the changes in sleep-wake architecture Summary: It is known that orexin (also known as hypocretin) is involved in waking. The results
Insomnia following hypocretin2-saporin lesions of the substantia nigra. Read More »
Mattsson A, Lindqvist E, Ogren SO, Olson L (2005) Increased phencyclidine-induced hyperactivity following cortical cholinergic denervation. Neuroreport 16(16):1815-1819. doi: 10.1097/01.wnr.0000185018.29316.87 Summary: A potential contribution to schizophrenia is altered cholinergic function. The authors investigated how lesioning cholinergic corticopetal projections might affect glutaminergic activity. Rats were injected with 0.134 µg of 192-IgG-SAP (Cat. #IT-01) into the nucleus
Kim DM, Ahn CW, Kim KR, Hong SW, Nam MS, Cha BS, Lim SK, Lee HC, Lee EJ (2005) Duodenal somatostatinoma associated with diabetic ketoacidosis presumably caused by somatostatin-28 hypersecretion. J Clin Endocrinol Metab 90(11):6310-6315. doi: 10.1210/jc.2004-1904 PMID: 16105971 Related Products: Somatostatin-28 Rabbit Polyclonal (Cat. #AB-05)
New Fluorescent Antibody: Cy3-labeled Anti-murine NGFr (Cat. #AB-N01APFL3) Advanced Targeting Systems introduces a new help in immunostaining: The antibody to mouse nerve growth factor receptor (NGFr, low affinity neurotrophin receptor, p75) conjugated to Cy3. The antibody is our widely-used rabbit polyclonal that has been affinity purified (Cat. #AB-N01AP). As can be seen in the figure
Targeting Tools: Cy3-labeled Anti-murine NGFR Read More »
Q: We just completed surgeries where we implanted third ventricular cannulas and temporary bilatera cannulas directed into the nucleus tractus solitarius in the brainstem of animals. We injected either the Blank-SAP control toxin (Cat. #IT-21) or the experimental material Oxytocin-SAP into the bilateral NTS cannulae over a 30-second period. However, within the next week —
Thinschmidt JS, Frazier CJ, King MA, Meyer EM, Papke RL (2005) Septal innervation regulates the function of alpha7 nicotinic receptors in CA1 hippocampal interneurons. Exp Neurol 195(2):342-352. doi: 10.1016/j.expneurol.2005.05.006 Summary: The authors examined whether hippocampal innervation by medial septum/diagonal band of Broca projections is necessary for normal a7 receptor function. 1 µg of 192-Saporin (Cat.
Pang K, Smith H (2005) Featured Article: Effects of intraseptal orexin-saporin on spatial memory. Targeting Trends 6(4) Related Products: Orexin-B-SAP (Cat. #IT-20) Read the featured article in Targeting Trends. See Also: Smith HR et al. Orexin-saporin lesions of the medial septum impair spatial memory. Neuroscience 132(2):261-271, 2005.
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Contributed by Kevin Pang and Heidi Smith, Bowling Green State University, Dept Psychology, Bowling Green, Ohio Hypocretin (or orexin) neurons are located in the hypothalamus and have been implicated in various functions including sleep, arousal and feeding. One area receiving dense hypocretin projections and expressing hypocretin-2 receptors (H-2r) is the medial septum (MS), an area
Cover Article: Effects of Intraseptal Orexin-Saporin on Spatial Memory Read More »
Suzuki R, Rahman W, Rygh LJ, Webber M, Hunt SP, Dickenson AH (2005) Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. Pain 117(3):292-303. doi: 10.1016/j.pain.2005.06.015 Summary: The anticonvulsant, gabapentin, is thought to modulate calcium channel function. In animals, it also affects abnormal pain function. 10 µl of 1 µM SP-SAP (Cat. #IT-07)