One of the most important features of the Advanced Targeting Systems product line is the availability of control toxins that allow the researcher to fully evaluate results of the treatment of cells or animals with targeted toxins. For instance, anti-DBH-SAP is targeted with a mouse monoclonal antibody. Its control partner is mouse IgG-SAP, that is, […]
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Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL (2005) Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. J Neurosci 25(14):3651-3660. doi: 10.1523/JNEUROSCI.0252-05.2005 PMID: 15814796 Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)
Q: We are re-examining some data collected using an immunotoxin not prepared by your company (VChAT-sap). Our results in vivo indicated that there were non-specific effects although the creators claimed it was specific. We ran a Western Blot and determined that about half the saporin was not bound to the antibody. This may have been
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Northrop LE, Cameron N, Erskine M (2005) Featured Article: Noradrenergic inputs to the medial amygdala originate in the A1 and A2 cells groups and release norepinephrine after mating stimulation sufficient to induce pseudopregnancy. Targeting Trends 6(2) Related Products: Anti-DBH-SAP (Cat. #IT-03) Read the featured article in Targeting Trends.
Mancuso M, Davidzon G, Kurlan RM, Tawil R, Bonilla E, Di Mauro S, Powers JM (2005) Hereditary ferritinopathy: a novel mutation, its cellular pathology, and pathogenetic insights. J Neuropathol Exp Neurol 64(4):280-294. doi: 10.1093/jnen/64.4.280 PMID: 15835264 Related Products: Malondialdehyde Rabbit Polyclonal, Conjugated (Cat. #AB-T090)
As most of you know, SP-SAP is a potential therapeutic that ATS is developing for use in the elimination of chronic pain. For the past seven years, preclinical studies have been carried out in the rat, safety and dosing studies completed in the dog and the first of two toxicology studies has begun in the
SP-SAP: How It’s Different From Substance P Antagonists Read More »
Contributed by Lesley E. Northrop, Nicole Cameron and Mary Erskine, Department of Biology, Boston University The posterodorsal medial amygdala (MePD) is involved in processing the information from genito- sensory stimuli which is needed for mating-induced pseudopregnancy. The amygdala complex is known to be involved in memory storage and consolidation, processes known to be influenced by
Mothet JP, Pollegioni L, Ouanounou G, Martineau M, Fossier P, Baux G (2005) Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine. Proc Natl Acad Sci U S A 102(15):5606-5611. doi: 10.1073/pnas.0408483102 PMID: 15800046 Related Products: D-Serine Rabbit Polyclonal, Conjugated (Cat. #AB-T048)
Ross RS, McGaughy J, Eichenbaum H (2005) Acetylcholine in the orbitofrontal cortex is necessary for the acquisition of a socially transmitted food preference. Learn Mem 12(3):302-306. doi: 10.1101/lm.91605 Summary: Cortical involvement in social transmission of food preference (STFP) has not been established, but the importance of the orbitofrontal cortex (OFC) in odor-guided learning is known.
Pagliardini S, Adachi T, Ren J, Funk GD, Greer JJ (2005) Fluorescent tagging of rhythmically active respiratory neurons within the pre-Bötzinger complex of rat medullary slice preparations. J Neurosci 25:2591-2596. doi: 10.1523/JNEUROSCI.4930-04.2005 PMID: 15758169 Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)