Wu M, Kc P, Mack SO, Haxhiu MA (2006) Ablation of vagal preganglionic neurons innervating the extra-thoracic trachea affects ventilatory responses to hypercapnia and hypoxia. Respir Physiol Neurobiol 152(1):36-50. doi: 10.1016/j.resp.2005.07.002
Summary: Hypercapnia, an excess of CO2 in the blood, is thought to stimulate the release of acetylcholine by airway-related vagal preganglionic neurons (AVPNs). AVPNs in the nucleus ambiguus (NA) were lesioned with ten 1-µl injections of CTB-SAP (Cat. #IT-14) into the trachealis muscle of rats. Treated animals maintained rhythmic breathing patterns, but episodes of increased respiratory rate in response to hypercapnia were significantly reduced.
Related Products: CTB-SAP (Cat. #IT-14)