Wiley RG, Lappi DA (2005) Molecular neurosurgery with targeted toxins. Humana Press, Totowa, New Jersey. Summary: The idea behind the book was to provide a road map for the users of Molecular Neurosurgery to see how experienced scientists used these exceptional reagents in their work. Experiments with several targeted toxins are described, and readers can […]
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Kim I, Wilson RE, Wellman CL (2005) Aging and cholinergic deafferentation alter GluR1 expression in rat frontal cortex. Neurobiol Aging 26(7):1073-1081. doi: 10.1016/j.neurobiolaging.2004.09.005 Summary: Neuronal plasticity is involved in several processes during adulthood, including learning and memory, and recovery from injury. Recent evidence suggests that aging reduces this plasticity. The authors used 0.15 µg injections
Aging and cholinergic deafferentation alter GluR1 expression in rat frontal cortex. Read More »
Harrell LE, Parsons DS, Kolasa K (2005) Pro- and anti-apoptotic evidence for cholinergic denervation and hippocampal sympathetic ingrowth in rat dorsal hippocampus. Exp Neurol 194(1):182-190. doi: 10.1016/j.expneurol.2005.02.009 Summary: Cholinergic denervation of the hippocampus results in hippocampal sympathetic ingrowth (HSI) of fibers from the superior cervical ganglion; this ingrowth may exert an anti-apoptotic effect. After 1-µg
Pappas BA, Payne KB, Fortin T, Sherren N (2005) Neonatal lesion of forebrain cholinergic neurons: Further characterization of behavioral effects and permanency. Neuroscience 133(2):485-492. doi: 10.1016/j.neuroscience.2005.02.040 Summary: Neonatal rats treated with bilateral intracerebroventricular injections of 300 ng of 192-Saporin (Cat. #IT-01) showed basal forebrain cholinergic neuron loss that was still evident at 24 months of
Abe T, Ohshita N, Sugiyo S, Moritani M, Kobayashi M, Takemura M (2005) Elimination of neurokinin-1 receptor neurons in caudal nucleus reverses the effects of systemic bicuculline on c-Fos expression in rat trigeminal sensory nucleus: I. High intensity electrical stimulation of the trigeminal ganglion. Neuroscience 133(3):739-747. doi: 10.1016/j.neuroscience.2005.03.021 Summary: The authors investigated the role of
Pagliardini S, Ren J, Wevrick R, Greer JJ (2005) Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin. Am J Pathol 167(1):175-191. doi: 10.1016/S0002-9440(10)62964-1 PMID: 15972963 Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)
Zhang RX, Wang L, Liu B, Qiao JT, Ren K, Berman BM, Lao L (2005) Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation. Brain Res 1048(1-2):235-240. doi: 10.1016/j.brainres.2005.05.008 Summary: Electroacupuncture has been shown to significantly reduce inflammatory hyperalgesia. To examine whether this effect is modulated by spinal mu opioid receptors,
Mohapel P, Leanza G, Kokaia M, Lindvall O (2005) Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Neurobiol Aging 26:939-946. doi: 10.1016/j.neurobiolaging.2004.07.015 Summary: New hippocampal neurons that are thought to be involved in memory formation are generated in the dentate gyrus (DG) throughout adulthood. In this study, rats were injected at various sites with 192-Saporin
Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Read More »
Smith HR, Pang KC (2005) Orexin-saporin lesions of the medial septum impair spatial memory. Neuroscience 132(2):261-271. doi: 10.1016/j.neuroscience.2004.12.037 Summary: The medial septum and diagonal band of Broca (MSDB) have been shown to be important for spatial learning and memory. The authors investigated the role orexin-containing neurons from the hypothalamus play in these processes. Rats were
Orexin-saporin lesions of the medial septum impair spatial memory. Read More »
Paban V, Jaffard M, Chambon C, Malafosse M, Alescio-Lautier B (2005) Time course of behavioral changes following basal forebrain cholinergic damage in rats: Environmental enrichment as a therapeutic intervention. Neuroscience 132(1):13-32. doi: 10.1016/j.neuroscience.2004.11.024 Summary: In this study the authors examined the effects of 192-Saporin (Cat. #IT-01) administration to the medial septum (37.5 ng/side) and nucleus