Read the 2006 Newsletters and recent scientific references 2006, issue 1: The Biologically Active Cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, Retains High Affinity for CCK2 Receptors after Covalent Conjugation to Saporin / by Lai J, Zhang W, Badghisi H, Hruby VJ, Porreca F / featuring CCK-SAP (Cat. #IT-31) SFN Poster of the Year Targeting Talk: LPS Content […]
Targeting Trends 2006 Newsletter Read More »
Schmeisser H, Kontsek P, Esposito D, Gillette W, Schreiber G, Zoon KC (2006) Binding Characteristics of IFN-alpha Subvariants to IFNAR2-EC and Influence of the 6-Histidine Tag. J Interferon Cytokine Res 26(12):866-876. doi: 10.1089/jir.2006.26.866 PMID: 17238829 Related Products: Antibody to 6-His (Cat. #AB-20)
Ohtori S, Inoue G, Koshi T, Ito T, Doya H, Moriya H, Takahashi K (2006) Substance P-saporin down-regulates substance P receptor immunoreactive sensory dorsal root ganglion neurons innervating the lumbar intervertebral discs in rats. Spine 31:2987-2991. doi: 10.1097/01.brs.0000250306.12996.fa Summary: Neurokinin-1 (NK-1) receptor expressing neurons that innervate lumbar intervertebral discs may be involved in lower back
Cabrera SM, Chavez CM, Corley SR, Kitto MR, Butt AE (2006) Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility. Behav Neurosci 120:298-306. doi: 10.1037/0735-7044.120.2.298 Summary: In humans, one aspect of cognitive flexibility is being able to shift attention under a variety of pressures. Here the authors suggest that lesions to the cholinergic nucleus
Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility. Read More »
Watson CS, Alyea RA, Hawkins BE, Thomas ML, Cunningham KA, Jakubas AA (2006) Estradiol effects on the dopamine transporter – protein levels, subcellular location, and function. J Mol Signal 1:5. doi: 10.1186/1750-2187-1-5 PMID: 17224081 Related Products: Dopamine Transporter Rat Monoclonal (DAT-ECD) (Cat. #AB-N17)
Ritter S, Dinh TT, Li AJ (2006) Hindbrain catecholamine neurons control multiple glucoregulatory responses. Physiol Behav 89(4):490-500. doi: 10.1016/j.physbeh.2006.05.036 Summary: Glucose deficit evokes many responses in the brain. Recently these workers have been focusing on mechanisms eliciting glucoregulatory responses; the focus has settled on catecholaminergic neurons in the hindbrain. In a series of experiments rats
Hindbrain catecholamine neurons control multiple glucoregulatory responses. Read More »
Vera-Portocarrero LP, Zhang ET, King T, Ossipov MH, Vanderah TW, Lai J, Porreca F (2007) Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. Pain 129:35-45. doi: 10.1016/j.pain.2006.09.033 Summary: Administration of opioids can induce hyperalgesia in humans and other mammals. In this work the authors examined the role
Estève MA, Carré M, Bourgarel-Rey V, Kruczynski A, Raspaglio G, Ferlini C, Braguer D (2006) Bcl-2 down-regulation and tubulin subtype composition are involved in resistance of ovarian cancer cells to vinflunine. Mol Cancer Ther 5(11):2824-2833. doi: 10.1158/1535-7163.MCT-06-0277 PMID: 17121929 Related Products: Antibody to Detyrosinated Alpha Tubulin (AA10 (1A11)) (Cat. #AB-V42)
Fransson J, Borrebaeck CA (2006) The nuclear DNA repair protein Ku70/80 is a tumor-associated antigen displaying rapid receptor mediated endocytosis. Int J Cancer 119(10):2492-2496. doi: 10.1002/ijc.22212 Summary: The protein Ku70/80 is expressed in the nucleus of all cells. Tumor cell lines, however, have been shown to express Ku70/80 on the cell surface. In this study,
Abdala AP, Schoorlemmer GH, Colombari E (2006) Ablation of NK(1) receptor bearing neurons in the nucleus of the solitary tract blunts cardiovascular reflexes in awake rats. Brain Res 1119(1):165-173. doi: 10.1016/j.brainres.2006.08.059 Summary: Cardiovascular function is largely controlled by the nucleus of the tractus solitarius (NTS). This work focuses on the baroreflex, cardiopulmonary chemoreflex, and arterial