Author name: Kristen Hartman

Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells.

Domico LM, Cooper KR, Bernard LP, Zeevalk GD (2007) Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology 28:1079-1091. doi: 10.1016/j.neuro.2007.04.008 PMID: 17597214 Summary: This work explores the mechanisms of neuronal damage associated with the ethylene-bis-dithiocarbamate fungicide mancozeb (MZ). In order to obtain a […]

Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Read More »

Specificity and generality of the involvement of catecholaminergic afferents in hypothalamic responses to immune insults.

Schiltz JC, Sawchenko PE (2007) Specificity and generality of the involvement of catecholaminergic afferents in hypothalamic responses to immune insults. J Comp Neurol 502:455-467. doi: 10.1002/cne.21329 Summary: Interleukin-1 (IL-1) is one of the cytokines that mediates interactions between the immune system and the central nervous system. 380-ng injections of anti-DBH-SAP (Cat. #IT-03) were made into

Specificity and generality of the involvement of catecholaminergic afferents in hypothalamic responses to immune insults. Read More »

Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression.

Bak SP, Walters JJ, Takeya M, Conejo-Garcia JR, Berwin BL (2007) Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Cancer Res 67:4783-4789. doi: 10.1158/0008-5472.CAN-06-4410 Summary: Vascular leukocytes (VLC) are immunosuppressive cells that facilitate tumor progression in ovarian cancer. One potential tumor therapy is to eliminate these cells. The authors determined that scavenger receptor-A is

Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Read More »

Guanidinylated-Neomycin delivers large, bioactive cargo into cells through a heparan sulfate dependent pathway.

Elson-Schwab L, Garner OB, Schuksz M, Esko JD, Tor Y (2007) Guanidinylated-Neomycin delivers large, bioactive cargo into cells through a heparan sulfate dependent pathway. J Biol Chem 282(18):13585-13591. doi: 10.1074/jbc.M700463200 Summary: The uptake of high molecular weight drugs into cells is a stumbling block for some potential therapeutics. Using a neomycin derivative in which guanidinium

Guanidinylated-Neomycin delivers large, bioactive cargo into cells through a heparan sulfate dependent pathway. Read More »

Anticonvulsant effects of damage to structures involved in seizure induction in rats exposed to soman.

Myhrer T, Enger S, Aas P (2007) Anticonvulsant effects of damage to structures involved in seizure induction in rats exposed to soman. Neurotoxicology 28(4):819-828. doi: 10.1016/j.neuro.2007.03.010 Summary: Soman is a nerve agent that irreversibly inhibits acetylcholinesterase, resulting in respiratory dysfunction, seizures, convulsions, coma, and death. In this work the authors investigated whether elimination of cholinergic

Anticonvulsant effects of damage to structures involved in seizure induction in rats exposed to soman. Read More »

Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy.

Gibbs RB, Johnson DA (2007) Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy. Neurobiol Learn Mem 88:19-32. doi: 10.1016/j.nlm.2007.03.007 Summary: It has been well established that the cholinergic system of the basal forebrain plays a critical role in many cognitive processes. This work

Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy. Read More »

Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin.

Hess PR, Barnes C, Woolard MD, Johnson MD, Cullen JM, Collins EJ, Frelinger JA (2007) Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin. Blood 109:3300-3307. doi: 10.1182/blood-2006-06-028001 Objective: To discover if pathogenic T cells could be selectively deleted. Summary: A single injection of

Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin. Read More »

Extensive training in a maze task reduces neurogenesis in the adult rat dentate gyrus probably as a result of stress.

Aztiria E, Capodieci G, Arancio L, Leanza G (2007) Extensive training in a maze task reduces neurogenesis in the adult rat dentate gyrus probably as a result of stress. Neurosci Lett 416(2):133-137. doi: 10.1016/j.neulet.2007.01.069 Summary: Ascending cholinergic inputs from the basal forebrain modulate hippocampal neurogenesis, although it is not clear if the modulation is direct

Extensive training in a maze task reduces neurogenesis in the adult rat dentate gyrus probably as a result of stress. Read More »

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